Radiotherapy enhancement with gold nanoparticles
Radiotherapy enhancement with gold nanoparticles
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DOI：
10.1211/jpp.60.8.0005
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发表时间：
2008-08-01
影响因子：
3.3
通讯作者：
Smilowitz, Henry M.
中科院分区：
文献类型：
--
作者：
Hainfeld, James F.;Dilmanian, F. Avraham;Smilowitz, Henry M.
Gold is an excellent absorber of X-rays. If tumours could be loaded with gold, this would lead to a higher dose to the cancerous tissue compared with the dose received by normal tissue during a radiotherapy treatment. Calculations indicate that this dose enhancement can be significant, even 200% or greater. In this paper, the physical and biological parameters affecting this enhancement are discussed. Gold nanoparticles have shown therapeutic efficacy in animal trials and these results are reviewed. Some 86% long-term (> 1 year) cures of EMT-6 mouse mammary subcutaneous tumours was achieved with an intravenous injection of gold nanoparticles before irradiation with 250-kVp photons, whereas only 20% were cured with radiation alone. The clinical potential of this approach is also discussed.
