FUNCTIONAL AND EFFECTIVE CONNECTIVITY IN SUBTHALAMIC LOCAL FIELD POTENTIAL RECORDINGS OF PATIENTS WITH PARKINSON'S DISEASE
FUNCTIONAL AND EFFECTIVE CONNECTIVITY IN SUBTHALAMIC LOCAL FIELD POTENTIAL RECORDINGS OF PATIENTS WITH PARKINSON'S DISEASE
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DOI：
10.1016/j.neuroscience.2013.07.028
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发表时间：
2013-10-10
期刊：
影响因子：
3.3
通讯作者：
Nikulin, V. V.
中科院分区：
文献类型：
--
作者：
Hohlefeld, F. U.;Huchzermeyer, C.;Nikulin, V. V.
在帕金森氏病（PD）中，左旋多巴相关的β振荡的功率和长程时间相关性的变化已经得到证实，但从丘脑底核记录的局部场电位（LFP）中真实连接的存在和调制仍然是一个悬而未决的问题。本研究调查了10例PD患者在停用左旋多巴过夜（OFF）和单剂量左旋多巴给药（ON）后，在清醒休息时双侧记录的LFP。我们利用了对体积传导不敏感的连通性测量（功能连通性：相干性的非零虚部;有效连通性：相位斜率指数）。我们证明了在STN-LFP中在10-30 Hz的频率范围内存在神经元相互作用，而没有沿着沿着电极轨道的不同接触之间的相互作用的优先方向性。虽然左旋多巴给药后神经元相互作用的方向本身被保留，但功能连接和腹背信息流被药物调制。功能连接的关闭-打开差异与左旋多巴诱导的临床统一帕金森病评定量表评分的改善相关。我们假设，区域神经元的相互作用，反映在STN-LFP连接，可能是一个基础的核内空间特异性的脑深部电刺激。此外，我们的研究结果表明，潜在的使用体积传导不敏感的措施，连接在STN-LFP作为一个标记的临床运动症状的PD。(c)2013年IBRO。由爱思唯尔有限公司出版。保留所有权利。
In Parkinson's disease (PD) levodopa-associated changes in the power and long-range temporal correlations of beta oscillations have been demonstrated, yet the presence and modulation of genuine connectivity in local field potentials (LFP) recorded from the subthalamic nucleus (STN) remains an open question. The present study investigated LFP recorded bilaterally from the STN at wakeful rest in ten patients with PD after overnight withdrawal of levodopa (OFF) and after a single dose levodopa administration (ON). We utilized connectivity measures being insensitive to volume conduction (functional connectivity: non-zero imaginary part of coherency; effective connectivity: phase-slope index). We demonstrated the presence of neuronal interactions in the frequency range of 10-30 Hz in STN-LFP without a preferential directionality of interactions between different contacts along the electrode tracks. While the direction of neuronal interactions per se was preserved after levodopa administration, functional connectivity and the ventral-dorsal information flow were modulated by medication. The OFF-ON differences in functional connectivity were correlated with the levodopa-induced improvement in clinical Unified Parkinson's Disease Rating Scale scores. We hypothesize that regional neuronal interactions, as reflected in STN-LFP connectivity, might represent a basis for the intra-nuclear spatial specificity of deep brain stimulation. Moreover, our results suggest the potential use of volume conduction-insensitive measures of connectivity in STN-LFP as a marker of clinical motor symptoms in PD. (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.