Escape of DNA from a weakly biased thin nanopore: experimental evidence for a universal diffusive behavior.
Escape of DNA from a weakly biased thin nanopore: experimental evidence for a universal diffusive behavior.
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DOI：
10.1103/physrevlett.111.248301
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发表时间：
2013-12-13
影响因子：
8.6
通讯作者：
Golovchenko JA
中科院分区：
文献类型：
--
作者：
Hoogerheide DP;Albertorio F;Golovchenko JA
我们报告实验逃逸时间分布的双链DNA（dsDNA）分子最初通过一个薄的固态纳米孔的一半线程。尽管实验的几何形状和复杂的分子-液体-孔隙相互作用的潜在作用，我们发现一个普遍的行为的逃逸时间分布与一维的第一次通过制定一致。扩散常数取决于分子长度和孔径的测定。还讨论了在纳米孔中长时间扩散分子捕获的实际意义。
We report experimental escape time distributions of double-stranded DNA (dsDNA) molecules initially threaded halfway through a thin solid-state nanopore. We find a universal behavior of the escape time distributions consistent with a one-dimensional first passage formulation notwithstanding the geometry of the experiment and the potential role of complex molecule-liquid-pore interactions. Diffusion constants that depend on the molecule length and pore size are determined. Also discussed are the practical implications of long time diffusive molecule trapping in the nanopore.