Effectiveness of Non-penetrating Electroporation Applicators to Function as Impedance Spectroscopy Electrodes
Effectiveness of Non-penetrating Electroporation Applicators to Function as Impedance Spectroscopy Electrodes
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DOI：
10.1109/tdei.2009.5293948
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发表时间：
2009-10-01
影响因子：
3.1
通讯作者：
Llewellyn, J. Anthony
中科院分区：
文献类型：
--
作者：
Connolly, Richard J.;Rey, Jose I.;Llewellyn, J. Anthony
通常进行电穿孔以将药物和基因递送至包含组织的细胞。控制和确认输送的一种可能方式是通过使用阻抗谱。理想情况下，该工具不应干扰输送，并应结合使用电极、施源器进行输送。这项工作探讨了阻抗谱与非穿透表面喷头通常用于皮肤电穿孔。在收集和处理来自三种动物模型的9，000多个光谱后，确定测试的电极系统对获得的光谱没有显著影响。因此，目前使用的电穿孔施加器可以同时用于阻抗谱的收集。
Electroporation is commonly performed to deliver drugs and genes to cells comprising tissues. A possible way to control and confirm delivery is through the use of impedance spectroscopy. Ideally, this tool should not interfere with delivery and should incorporate the use of electrodes, applicators, used for delivery. This work examines impedance spectra obtained with non-penetrating surface applicators commonly used for skin electroporation. After collecting and processing over 9,000 spectra from three animal models it was determined that the electrode systems tested would have no significant effect on the obtained spectra. Therefore, electroporation applicators currently in use could be used concurrently for the collection of impedance spectra.