Anabolic-androgenic steroid effects on sexual receptivity in ovariectomized rats
Anabolic-androgenic steroid effects on sexual receptivity in ovariectomized rats
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DOI：
10.1006/hbeh.1997.1422
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发表时间：
1997-12-01
影响因子：
3.5
通讯作者：
Clark, AS
中科院分区：
文献类型：
--
作者：
Blasberg, ME;Clark, AS
合成类固醇(AAS)化合物是运动员为增加体力和耐力而服用的合成雄激素。我们实验室最近的研究表明，AAS给药扰乱了Long-Evans大鼠的发情周期。本实验研究了6种常用的AAS化合物对去卵巢大鼠性感受性的影响。成年雌性Long-Evans大鼠连续6天注射苯甲酸雌二醇组(EB；2.0mgsc)，随后15d同时每日sc下列AAS化合物之一7.5 mg/kg：17α-甲基睾丸酮、甲基雄烯醇酮、十一酸诺酮、司坦唑醇、羟甲基美洛酮、环丙酸睾丸酮或石油载体。在第15天，所有雌性大鼠在试验前4h给予孕酮(1.0 mg/只)。在AAS治疗的第3天、第6天、第14天和第15天进行性接受性测试。虽然AAS对性接受性的影响的时间进程各不相同，但总体上的一些影响是明确的。例如，17α-甲基睾丸酮、甲基雄烯醇酮、己酸诺酮和司坦唑醇干扰了第14天的性接受能力的显示，而羟美洛酮和己酸睾丸酮则没有影响。各组大鼠在第15天注射黄体酮后表现出高度的性感受性。我们的结果表明，在去卵巢的大鼠中，AAS化合物对雌性性行为的抑制程度不同。(C)1997年学术出版社。
Anabolic-androgenic steroid (AAS) compounds are synthetic androgens taken by athletes to increase physical strength and endurance. Recent studies in our laboratory have demonstrated that AAS administration disrupts the estrous cycle of Long-Evans rats. The present experiments examined the effects of six commonly abused AAS compounds on sexual receptivity in ovariectomized rats. Adult female Long-Evans rats received estradiol benzoate (EB; 2.0 mu g/day sc) for 6 consecutive days followed by 15 days of EB concurrent with daily sc injections of 7.5 mg/kg of one of the following AAS compounds: 17 alpha-methyltestosterone, methandrostenolone, nandrolone decanoate, stanozolol, oxymetholone, testosterone cypionate, or the oil vehicle. On Day 15, all female rats received progesterone (1.0 mg/rat)4 h before testing. Tests for sexual receptivity were conducted on Days 3, 6, 14, and 15 of AAS treatment. Although the time course of AAS effects on sexual receptivity varied, some overall effects were clear. For example, 17 alpha-methyltestosterone, methandrostenolone, nandrolone decanoate, and stanozolol interfered with the display of sexual receptivity on Day 14, whereas oxymetholone and testosterone cypionate had no effect. Rats in all groups displayed high levels of sexual receptivity after receiving progesterone on Day 15. Our results show that AAS compounds vary in their degree of inhibition of female sexual behavior in ovariectomized rats. (C) 1997 Academic Press.