Inhibitory Effect of Acai (Euterpe oleracea Mart.) Pulp on IgE-Mediated Mast Cell Activation
Inhibitory Effect of Acai (Euterpe oleracea Mart.) Pulp on IgE-Mediated Mast Cell Activation
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DOI：
10.1021/jf2005707
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发表时间：
2011-05-25
影响因子：
6.1
通讯作者：
Hori-Tamura, Naoko
中科院分区：
文献类型：
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作者：
Horiguchi, Tomoko;Ishiguro, Nahoko;Hori-Tamura, Naoko
棕榈果巴西莓因其抗氧化剂清除能力而具有潜在的健康益处。用巴西莓果肉预处理IgE致敏的小鼠原代培养的肥大细胞，以剂量依赖性方式显著抑制抗原诱导的脱粒。同样，acai抑制IgE介导的脱粒和转录的细胞因子基因从培养的肥大细胞系大鼠嗜碱性白血病（RBL）-2H3细胞。Fcgl可选择性抑制Fc β RI信号通路。此外，Fc β RI介导的互补信号传导途径也被acai抑制。这些结果表明acai是IgE介导的肥大细胞活化的有效抑制剂。
The palm fruit acai is known to have potential health benefits due to its antioxidant scavenging capacities. Pretreatment of IgE-sensitized mouse primary cultured mast cells with acai pulp resulted in the dramatic suppression of antigen-induced degranulation in a dose-dependent manner. Similarly, acai suppressed IgE-mediated degranulation and transcription of the cytokine genes from a cultured mast cell line of rat basophilic leukemia (RBL)-2H3 cells. Acai could selectively inhibit Fc epsilon RI signaling pathways. Furthermore, the Fc epsilon RI-mediated complementary signaling pathway was also suppressed by acai. These results demonstrate that acai is a potent inhibitor of IgE-mediated mast cell activation.