Disease activity and emotional state in multiple sclerosis
Disease activity and emotional state in multiple sclerosis
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多发性硬化症的疾病活动性和情绪状态
DOI：
10.1002/ana.410130517
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发表时间：
1983
影响因子：
11.2
通讯作者：
Pat O'donnell
中科院分区：
文献类型：
--
作者：
Nancy P. Dalos;P. Rabins;B. Brooks;Pat O'donnell
通过使用28项子量表一般健康问卷（GHQ），对64例多发性硬化（MS）患者和23例脊髓损伤（SCI）对照患者的情绪障碍的患病率和性质进行了前瞻性研究。缓解期MS患者的平均GHQ评分为4.4分，急性加重期或进行性非缓解期MS患者的平均GHQ评分为15.7分，有显著差异（p <0.001）。情绪障碍的患病率在恶化或进展的患者中为90%，在稳定的患者中为39%，在SCI对照患者中为12%。情绪障碍的存在与年龄、性别或其他人口统计学变量、疾病的持续时间或严重程度或残疾程度无关。在缓解期MS患者组中，躯体主诉、焦虑和社会功能障碍比抑郁症状更普遍。
The prevalence and nature of emotional disturbance in patients with multiple sclerosis (MS) was studied prospectively in 64 MS patients and 23 spinal cord–injured (SCI) control patients by administration of the 28‐item subscale General Health Questionnaire (GHQ). MS patients in remission had a mean GHQ score of 4.4, and patients with acute exacerbation or progressive nonremitting MS had a mean score of 15.7, a significant difference (p < 0.001). The prevalence of emotional disturbance was 90% in exacerbating or progressing patients, 39% in stable patients, and 12% in SCI control patients. The presence of emotional disturbance was not related to age, sex, or other demographic variables, to duration or severity of disease, or to the degree of disability. In the group of MS patients in remission, somatic complaints, anxiety, and social dysfunction were more prevalent than symptoms of depression.