Neural crest cells and fetal alcohol spectrum disorders: Mechanisms and potential targets for prevention.
Neural crest cells and fetal alcohol spectrum disorders: Mechanisms and potential targets for prevention.
复制标题
神经嵴细胞和胎儿酒精谱系障碍：预防机制和潜在目标。
DOI：
10.1016/j.phrs.2023.106855
复制
发表时间：
2023-08
影响因子：
9.3
通讯作者：
Kannan, Maharajan
中科院分区：
文献类型：
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作者：
Chen, Shao-yu;Kannan, Maharajan
胎儿酒精谱系障碍（FASD）是一组由产前酒精暴露引起的可预防和非遗传性出生缺陷，可导致一系列认知，行为，情感和功能缺陷，以及颅面畸形和其他先天性缺陷。在胚胎发育过程中，神经嵴细胞（NCC）在发育胚胎中产生许多细胞类型方面起着关键作用，包括外周神经系统和颅面结构中的细胞。在这一关键时期的乙醇暴露可能对NCC诱导、迁移、分化和存活产生不利影响，导致FASD患者出现广泛的结构和功能异常。本文综述了乙醇对NCC诱导、迁移、分化和存活的不利影响。本文还探讨了乙醇诱导的NCC功能障碍的分子机制，如氧化应激，改变基因表达，细胞凋亡，表观遗传修饰和其他信号通路。此外，该综述强调了预防或减轻乙醇对NCC的有害影响和降低FASD风险的潜在治疗策略。总的来说，本文提供了一个全面的概述，目前的理解乙醇对NCC的影响及其在FASD中的作用，阐明未来的研究和干预的潜在途径。
Fetal alcohol spectrum disorders (FASD) are a group of preventable and nongenetic birth defects caused by prenatal alcohol exposure that can result in a range of cognitive, behavioral, emotional, and functioning deficits, as well as craniofacial dysmorphology and other congenital defects. During embryonic development, neural crest cells (NCCs) play a critical role in giving rise to many cell types in the developing embryos, including those in the peripheral nervous system and craniofacial structures. Ethanol exposure during this critical period can have detrimental effects on NCC induction, migration, differentiation, and survival, leading to a broad range of structural and functional abnormalities observed in individuals with FASD. This review article provides an overview of the current knowledge on the detrimental effects of ethanol on NCC induction, migration, differentiation, and survival. The article also examines the molecular mechanisms involved in ethanol-induced NCC dysfunction, such as oxidative stress, altered gene expression, apoptosis, epigenetic modifications, and other signaling pathways. Furthermore, the review highlights potential therapeutic strategies for preventing or mitigating the detrimental effects of ethanol on NCCs and reducing the risk of FASD. Overall, this article offers a comprehensive overview of the current understanding of the impact of ethanol on NCCs and its role in FASD, shedding light on potential avenues for future research and intervention.
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DOI：
10.1016/j.reprotox.2013.08.003
发表时间：
2013-12
期刊：
Reproductive toxicology (Elmsford, N.Y.)
影响因子：
--
作者：
Chen X;Liu J;Chen SY
通讯作者：
Chen SY
影响因子：
5.3
作者：
Yuan F;Chen X;Liu J;Feng W;Cai L;Wu X;Chen SY
通讯作者：
Chen SY
影响因子：
2.3
作者：
Chen, SY;Periasamy, A;Sulik, KK
通讯作者：
Sulik, KK
影响因子：
7.3
作者：
Chen, X.;Liu, J.;Chen, S-Y
通讯作者：
Chen, S-Y
影响因子：
9
作者：
通讯作者：
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