Pharmacological Targeting of Cell Cycle, Apoptotic and Cell Adhesion Signaling Pathways Implicated in Chemoresistance of Cancer Cells.
Pharmacological Targeting of Cell Cycle, Apoptotic and Cell Adhesion Signaling Pathways Implicated in Chemoresistance of Cancer Cells.
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DOI：
10.3390/ijms19061690
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发表时间：
2018-06-06
影响因子：
5.6
通讯作者：
Kipling D
中科院分区：
文献类型：
--
作者：
Alimbetov D;Askarova S;Umbayev B;Davis T;Kipling D
化疗药物的目标是癌细胞的生理分化特征，因为它们往往比正常细胞更活跃地增殖。由于肠道和免疫系统中高度增殖的正常细胞死亡，它们具有众所周知的副作用。近年来，由于肿瘤研究的快速发展，癌症治疗发生了巨大变化。癌症治疗的发展，即手术、放疗、细胞毒性化疗和选择性治疗方法，由于更好地了解肿瘤的特点，大大提高了癌症的生存率。然而，许多化疗方案仍然失败，转移性癌症治疗中90%的药物失败是由于化疗耐药，因为癌细胞最终会对化疗药物产生耐药性。化疗耐药是由参与细胞周期、细胞凋亡和细胞粘附等细胞机制的各种蛋白质的基因突变引起的，靶向这些机制可以改善癌症治疗的结果。癌症治疗的最新进展集中在联合治疗上，即细胞对化疗药物敏感，使用靶向途径的抑制剂诱导化疗耐药，从而有希望克服耐药性问题。在这篇综述中，我们讨论了细胞周期，细胞凋亡和细胞粘附在癌症化疗耐药机制中的作用，可能针对这些途径的药物，从而为癌症治疗提供新的治疗方法。
Chemotherapeutic drugs target a physiological differentiating feature of cancer cells as they tend to actively proliferate more than normal cells. They have well-known side-effects resulting from the death of highly proliferative normal cells in the gut and immune system. Cancer treatment has changed dramatically over the years owing to rapid advances in oncology research. Developments in cancer therapies, namely surgery, radiotherapy, cytotoxic chemotherapy and selective treatment methods due to better understanding of tumor characteristics, have significantly increased cancer survival. However, many chemotherapeutic regimes still fail, with 90% of the drug failures in metastatic cancer treatment due to chemoresistance, as cancer cells eventually develop resistance to chemotherapeutic drugs. Chemoresistance is caused through genetic mutations in various proteins involved in cellular mechanisms such as cell cycle, apoptosis and cell adhesion, and targeting those mechanisms could improve outcomes of cancer therapy. Recent developments in cancer treatment are focused on combination therapy, whereby cells are sensitized to chemotherapeutic agents using inhibitors of target pathways inducing chemoresistance thus, hopefully, overcoming the problems of drug resistance. In this review, we discuss the role of cell cycle, apoptosis and cell adhesion in cancer chemoresistance mechanisms, possible drugs to target these pathways and, thus, novel therapeutic approaches for cancer treatment.
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影响因子：
64.8
作者：
Bartkova, Jirina;Rezaei, Nousin;Gorgoulis, Vassilis G.
通讯作者：
Gorgoulis, Vassilis G.
影响因子：
5.2
作者：
Cicenas J;Kalyan K;Sorokinas A;Jatulyte A;Valiunas D;Kaupinis A;Valius M
通讯作者：
Valius M
DOI：
10.1111/igc.0b013e3181a8331f
发表时间：
2009-07-01
影响因子：
4.8
作者：
Bellone, Stefania;Siegel, Eric R.;Santin, Alessandro D.
通讯作者：
Santin, Alessandro D.
影响因子：
4.8
作者：
Cai, Beibei;Chang, Sandra H.;Xia, Zhengui
通讯作者：
Xia, Zhengui
影响因子：
20.3
作者：
Chen, Q;Van der Sluis, PC;Dalton, WS
通讯作者：
Dalton, WS