Radiation sensitization of bacterial spores by cis-dichlorodiammineplatinum(II).
Radiation sensitization of bacterial spores by cis-dichlorodiammineplatinum(II).
复制标题
顺式二氯二氨铂 (II) 对细菌孢子的辐射致敏。
DOI：
10.2307/3574476
复制
发表时间：
1976
影响因子：
3.4
通讯作者：
E. L. Powers
中科院分区：
文献类型：
--
作者：
R. Richmond;E. L. Powers
The x irradiation of B. megaterium spores in aqueous suspension in the presence of cis-dichlorodiammineplatinum(II) (CPCA) results in biphasic survival curves showing pronounced increases in radiation sensitivity in N/sub 2/ , O/sub 2/, and in N/sub 2/O in the low-dose portion of the response. In N/sub 2/, the degree of CPCA-induced sensitization fully equals that due to O/sub 2/ alone. In the presence of O/sub 2/ and N/sub 2/O, the added component of sensitization is half that obtained under N/sub 2/ saturation. Additional results are also obtained in the presence of hydroxyl radical scavengers, and in the presence of N/sub 2/O. These results are additionally significant considering that CPCA has been successfully used in animal studies as an antitumor drug.
