Visuoperceptual functioning differs in 9-to 12-year olds prenatally exposed to cigarettes and marihuana
Visuoperceptual functioning differs in 9-to 12-year olds prenatally exposed to cigarettes and marihuana
复制标题
DOI：
10.1016/s0892-0362(99)00046-x
复制
发表时间：
2000-01-01
影响因子：
2.9
通讯作者：
Watkinson, B
中科院分区：
文献类型：
--
作者：
Fried, PA;Watkinson, B
对146名9- 12岁的儿童进行了视觉感知性能检查，这些儿童在产前暴露于大麻和香烟。受试者是一项正在进行的纵向研究的参与者，来自低风险，主要是中产阶级样本。这些任务的复杂性从需要基本视觉感知技能到需要大量整合和认知操作这些技能不等。趋势分析显示，产前吸烟暴露与反映基本视觉感知功能的总体评分之间存在剂量依赖性负相关。在考虑到潜在的产前混乱、产前和产后二手烟暴露以及任务的非感知要求后，这种关联仍然存在。吸烟者的后代在基本视觉感知领域的表现较差，这表明他们在更复杂的视觉感知任务中表现较差。相反，产前大麻暴露与基本的视觉感知功能无关，但与视觉问题解决情况下的表现呈负相关。大麻的研究结果的解释进行了讨论，与执行功能，现存的前额叶文学，和早期的观察这个样本的“自上而下”的综合能力。(C)1999 Elsevier Science Inc. All rights reserved.
Visuoperceptual performance was examined in 146 9- to 12-year old children for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects, participants in an ongoing longitudinal study, were from a low-risk, predominantly middle class sample. The tasks ranged in complexity from those that required basic visuoperceptual skills to those that required considerable integration and cognitive manipulation of such skills. Trend analysis revealed a dose dependent negative association between prenatal cigarette exposure and an overall score reflecting basic visuoperceptual functioning. This association remained after consideration of potential prenatal confounds, pre- and postnatal secondhand smoke exposure, and the nonperceptual demands of the tasks. This poorer performance in the basic visuoperceptual domain underlay a poorer performance in more complex visuoperceptual tasks among the offspring of cigarette smokers. In contrast, prenatal marihuana exposure was not associated with basic visuoperceptual functioning but was negatively associated with performance in visual problem solving situations. The interpretation of the marihuana findings is discussed in relation to a "top-down" integrative ability associated with executive function, the extant prefrontal literature, and earlier observations of this sample. (C) 1999 Elsevier Science Inc. All rights reserved.