Acylsilanes in Iridium-Catalyzed Directed Amidation Reactions and Formation of Heterocycles via Siloxycarbenes
Acylsilanes in Iridium-Catalyzed Directed Amidation Reactions and Formation of Heterocycles via Siloxycarbenes
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DOI：
10.1002/anie.201508501
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发表时间：
2015-12-14
影响因子：
16.6
通讯作者：
Bolm, Carsten
中科院分区：
文献类型：
--
作者：
Becker, Peter;Pirwerdjan, Ramona;Bolm, Carsten
将邻氨基芳酰基硅烷暴露于可见光或热导致环化反应，该环化反应经由作为关键中间体的双环卡宾提供N-杂环化合物。以前未报道的起始原料已通过在铱催化剂存在下芳族酰基硅烷的直接酰胺化，然后进行N-烷基化来制备。
Exposing ortho-amido aroylsilanes to visible light or heat leads to cyclization reactions that provide N-heterocyclic compounds via siloxycarbenes as key intermediates. The previously unreported starting materials have been prepared by directed amidations of aromatic acylsilanes in the presence of an iridium catalyst followed by N-alkylation.