Family history of diabetes as a potential public health tool
Family history of diabetes as a potential public health tool
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DOI：
10.1016/s0749-3797(02)00588-3
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发表时间：
2003-02-01
影响因子：
5.5
通讯作者：
Edwards, KL
中科院分区：
文献类型：
--
作者：
Harrison, TA;Hindorff, LA;Edwards, KL
鉴于与2型糖尿病相关的发病率和死亡率很高，重要的是公共卫生寻求延迟或预防这种疾病的发病的方法。2型糖尿病的危险因素已经很好地确定，包括潜在的遗传易感性。尽管有这些知识，以及在了解人类基因组方面的重大进展，2型糖尿病的患病率仍以惊人的速度上升。由于2型糖尿病是一种复杂的疾病，涉及遗传和环境因素的结合，因此尚不需要进行易感基因的DNA检测。然而，由于家族史除了其他因素外还反映了遗传易感性，因此它可能是预防疾病的有用公共卫生工具。当评估家族史作为公共卫生工具时，需要考虑几个重要问题，包括分析和临床有效性以及使用家族史作为筛查工具的临床效用。这些问题，以及评估家族史作为一个危险因素的流行病学证据的审查将review.Overall，家族史的方法似乎是一个有前途的新的公共卫生工具，以打击日益增长的糖尿病在美国的流行。应提供充足的资金，以进一步评价这一方法，并开发适当的工具，用于这一重要领域的研究活动。
Given the substantial morbidity and mortality associated with type 2 diabetes, it is important that public health seek ways to delay or prevent the onset of this condition. Risk factors for type 2 diabetes are well established and include underlying genetic susceptibility. Despite this knowledge, as well as significant advances in understanding the human genome, the prevalence of type 2 diabetes continues to rise at an alarming rate. Because type 2 diabetes is a complex condition involving a combination of genetic and environmental factors, DNA testing for susceptibility genes is not yet warranted. However, because family history reflects genetic susceptibility in addition to other factors, it may be a useful public health tool for disease prevention. When evaluating family history as a public health tool, several important issues need to be considered, including the analytic and clinical validity and the clinical utility of using family history as a screening tool. These issues as well as a review of the epidemiologic evidence evaluating family history as a risk factor will be reviewed.Overall, a family history approach appears to be a promising new public health tool to fight the growing epidemic of diabetes in the United States. Adequate levels of funding to further evaluate this approach and to develop appropriate tools should be made available for research activities focused on this important area.