APOPTOSIS AND THE CELL-CYCLE
APOPTOSIS AND THE CELL-CYCLE
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DOI：
10.1016/0955-0674(95)80066-2
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发表时间：
1995-12-01
影响因子：
7.5
通讯作者：
HARRINGTON, E
中科院分区：
文献类型：
--
作者：
EVAN, GI;BROWN, L;HARRINGTON, E
细胞凋亡是一个进化上保守的“自杀”程序，存在于所有后生动物细胞中。尽管其高度保守的性质，它只是最近才被确定的任何细胞凋亡的分子机制。几条推理路线表明，细胞凋亡和细胞增殖在某种程度上是一致的：许多促进细胞周期进程的癌基因也诱导细胞凋亡;细胞周期或DNA完整性的损伤是细胞凋亡的有力触发因素;关键的肿瘤抑制蛋白p105（Rb）和p53对细胞活力和细胞周期进程都有直接影响。然而，很少有证据表明细胞凋亡和细胞周期具有共同的分子机制。此外，现在已知半胱氨酸蛋白酶的白细胞介素-1 β转化酶（ICE）家族在细胞凋亡中起关键作用，但在细胞周期中没有可辨别的作用，认为这两个过程是离散的。
Apoptosis is an evolutionarily conserved 'suicide' programme present in all metazoan cells. Despite its highly conserved nature, it is only recently that any of the molecular mechanisms underlying apoptosis have been identified. Several lines of reasoning indicate that apoptosis and cell proliferation coincide to some degree: many oncogenes that promote cell cycle progression also induce apoptosis; damage to the cell cycle or to DNA integrity is a potent trigger of apoptosis; and the key tumour suppressor proteins, p105(rb) and p53, exert direct effects both on cell viability and on cell cycle progression. There is less evidence, however, to indicate that apoptosis and the cell cycle share common molecular mechanisms. Moreover, the interleukin-1 beta converting enzyme (ICE) family of cysteine proteases is now known to play a key role in apoptosis but has no discernible role in the cell cycle, arguing that the two processes are discrete.