Memory CD8+T cells in heterologous antiviral immunity and immunopathology in the lung
Memory CD8+T cells in heterologous antiviral immunity and immunopathology in the lung
复制标题
DOI：
10.1038/ni727
复制
发表时间：
2001-11-01
影响因子：
30.5
通讯作者：
Selin, LK
中科院分区：
文献类型：
--
作者：
Chen, HD;Fraire, AE;Selin, LK
病毒感染的呼吸道粘膜模型显示了记忆CD8+T细胞在异源免疫中的重要作用。淋巴细胞脉络膜脑膜炎病毒（LCMV）感染后产生的记忆CD8（+）T细胞在牛痘病毒（VV）急性感染期间在体内功能性激活，产生干扰素-γ（IFN-γ）。其中一些抗原特异性记忆细胞选择性地增加数量，从而导致原始 LCMV 特异性 T 细胞库的调节。此外，在 VV 感染期间，这些 LCMV 特异性 T 细胞发生器官选择性区室重新分布。这些 LCMV 特异性记忆 T 细胞的存在与 VV 清除率增强、死亡率降低和肺部免疫病理学显着变化相关。因此，预先存在的针对无关物质的记忆T细胞的参与可以改变粘膜免疫的动态和响应病原体的疾病过程。
A potent role for memory CD8(+) T cells in heterologous immunity was shown with a respiratory mucosal model of viral infection. Memory CD8(+) T cells generated after lymphocytic choriomeningitis virus (LCMV) infection were functionally activated in vivo to produce interferon-gamma (IFN-gamma) during acute infection with vaccinia virus (VV). Some of these antigen-specific memory cells selectively expanded in number, which resulted in modulation of the original LCMV-specific T cell repertoire. In addition, there was an organ-selective compartmental redistribution of these LCMV-specific T cells during VV infection. The presence of these LCMV-specific memory T cells correlated with enhanced VV clearance, decreased mortality and marked changes in lung immunopathology. Thus, the participation of pre-existing memory T cells specific to unrelated agents can alter the dynamics of mucosal immunity and disease course in response to a pathogen.