PREDOMINANCE OF A SINGLE GENOTYPE OF MYCOBACTERIUM-TUBERCULOSIS IN COUNTRIES OF EAST-ASIA
PREDOMINANCE OF A SINGLE GENOTYPE OF MYCOBACTERIUM-TUBERCULOSIS IN COUNTRIES OF EAST-ASIA
复制标题
DOI：
10.1128/jcm.33.12.3234-3238.1995
复制
发表时间：
1995-12-01
影响因子：
9.4
通讯作者：
VANEMBDEN, JDA
中科院分区：
文献类型：
--
作者：
VANSOOLINGEN, D;QIAN, LS;VANEMBDEN, JDA
对来自中华人民共和国的结核分枝杆菌菌株的群体结构分析表明，绝大多数菌株属于遗传上密切相关的群体，这些菌株共享大部分含IS6110 DNA的限制性片段，并且与其他重复DNA元件相关的DNA多态性，如多态性富含CC序列和直接重复序列，非常有限，由于这些菌株大多数来自北京省，我们将这一群命名为M.结核菌株该家族的菌株也被发现在蒙古、韩国和泰国等邻国占主导地位，而在其他大陆的国家中观察到这种菌株的低流行率。这些数据表明，Belling家族的菌株最近从具有选择优势的单一祖先扩展，推测长期的牛分枝杆菌卡介苗接种可能是北京基因型成功传播的选择力之一。
Analysis of the population structure of Mycobacterium tuberculosis strains from the People's Republic of China showed that the vast majority belong to a genetically closely related group, These strains shared the majority of their IS6110 DNA-containing restriction fragments, and also, the DNA polymorphism associated with other repetitive DNA elements, like the polymorphic CC-rich sequence and the direct repeat, was very limited, Because the majority of these strains originated from the province of Beijing, we designated this grouping the ''Beijing family'' of M. tuberculosis strains. Strains of this family were also found to dominate in neighboring countries such as Mongolia, South Korea, and Thailand, whereas a low prevalence of such strains was observed in countries on other continents, These data indicate that strains of the Belling family recently expanded from a single ancestor which had a selective advantage, It is speculated that long-term Mycobacterium bovis BCG vaccination may be one of the selective forces implicated in the successful spread of the Beijing genotype.