Enhancement of human immunodeficiency virus 1 replication in monocytes by 1,25-dihydroxycholecalciferol.
Enhancement of human immunodeficiency virus 1 replication in monocytes by 1,25-dihydroxycholecalciferol.
复制标题
1,25-二羟基胆钙化醇增强人类免疫缺陷病毒 1 在单核细胞中的复制。
DOI：
10.1073/pnas.88.15.6632
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发表时间：
1991
影响因子：
11.1
通讯作者：
Krane,SM
中科院分区：
文献类型：
--
作者：
Skolnik,PR;Jahn,B;Wang,MZ;Rota,TR;Hirsch,MS;Krane,SM
人类免疫缺陷病毒（HIV）的表达和复制受到严格的监管控制。我们证明，1，25-二羟基胆钙化醇[1，25-（OH）2D 3]可增强单核细胞系、外周血单核细胞和未分级外周血单核细胞中HIV-1嗜单核细胞和淋巴细胞株的复制高达10，000倍。因此，1，25（OH）2D 3是迄今为止描述的HIV-1复制的最有效调节剂之一。1，25（OH）2D 3的前体与其对1，25（OH）2D 3细胞内受体的亲和力成比例地增强HIV-1复制，表明1，25（OH）2D 3通过涉及该受体的机制影响HIV-1复制。这些研究可能对设计HIV-1感染的有效治疗方法具有重要意义。
Human immunodeficiency virus (HIV) expression and replication are under tight regulatory control. We demonstrate that 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] enhances the replication of monocyte- and lymphocyte-tropic strains of HIV-1 up to 10,000-fold in monocyte cell lines, peripheral blood monocytes, and unfractionated peripheral blood mononuclear cells. 1,25(OH)2D3 is therefore one of the most potent regulators of HIV-1 replication described to date. Precursors of 1,25(OH)2D3 enhance HIV-1 replication in proportion to their affinity for the 1,25(OH)2D3 intracellular receptor, suggesting that 1,25(OH)2D3 influences HIV-1 replication by mechanisms involving this receptor. These studies may have important implications for the design of effective therapy of HIV-1 infection.