Using Literature-Based Discovery to Explain Adverse Drug Effects
Using Literature-Based Discovery to Explain Adverse Drug Effects
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DOI：
10.1007/s10916-016-0544-z
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发表时间：
2016-08-01
影响因子：
5.3
通讯作者：
Rindflesch, Thomas C.
中科院分区：
文献类型：
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作者：
Hristovski, Dimitar;Kastrin, Andrej;Rindflesch, Thomas C.
我们报告了我们使用基于文献的发现 (LBD) 为报告的药物不良反应提供药理学和/或药物基因组学解释的研究。 LBD 的目标是通过分析科学文献和一些额外的资源（可选）来生成新颖且可能有用的假设。我们的假设是药物对某些基因或蛋白质有影响，并且这些基因或蛋白质与观察到的不良反应有关。因此，通过使用 LBD，我们试图找到将药物与报告的不良反应联系起来的基因或蛋白质。这些基因或蛋白质可用于深入了解造成不利影响的过程。初步结果表明，我们的方法有可能有助于解释报告的药物不良反应。
We report on our research in using literature-based discovery (LBD) to provide pharmacological and/or pharmacogenomic explanations for reported adverse drug effects. The goal of LBD is to generate novel and potentially useful hypotheses by analyzing the scientific literature and optionally some additional resources. Our assumption is that drugs have effects on some genes or proteins and that these genes or proteins are associated with the observed adverse effects. Therefore, by using LBD we try to find genes or proteins that link the drugs with the reported adverse effects. These genes or proteins can be used to provide insight into the processes causing the adverse effects. Initial results show that our method has the potential to assist in explaining reported adverse drug effects.