Discovery of the strong antioxidant selenoneine in tuna and selenium redox metabolism.
Discovery of the strong antioxidant selenoneine in tuna and selenium redox metabolism.
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DOI：
10.4331/wjbc.v1.i5.144
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发表时间：
2010-05-26
期刊：
影响因子：
--
通讯作者：
Yamashita, Michiaki
中科院分区：
文献类型：
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作者：
Yamashita, Yumiko;Yabu, Takeshi;Yamashita, Michiaki
从金枪鱼血液和组织中分离到一种新的含硒化合物硒酮，它是有机硒的主要存在形式。硒酮在咪唑环中含有硒原子，2-硒基-N（α），N（α），N（α）-三甲基-L-组氨酸，并且是麦角硫因的硒类似物。这种硒化合物具有很强的抗氧化能力，并与血红素蛋白（如血红蛋白和肌红蛋白）结合，以保护它们免受铁自动氧化，并与自由基和甲基汞（MeHg）反应。有机阳离子/肉毒碱转运蛋白OCTN 1转运硒酮和甲基汞，调节硒增强的抗氧化活性，并降低甲基汞毒性。因此，通过食用鱼类摄入硒因，可能会减少活性氧自由基的形成，这些活性氧自由基可以氧化DNA中的核苷酸，从而抑制致癌、慢性疾病和衰老。
A novel selenium-containing compound, selenoneine, has been isolated as the major form of organic selenium in the blood and tissues of tuna. Selenoneine harbors a selenium atom in the imidazole ring, 2-selenyl-N(alpha), N(alpha), N(alpha)-trimethyl-L-histidine, and is a selenium analog of ergothioneine. This selenium compound has strong antioxidant capacity and binds to heme proteins, such as hemoglobin and myoglobin, to protect them from iron auto-oxidation, and it reacts with radicals and methylmercury (MeHg). The organic cations/carnitine transporter OCTN1 transports selenoneine and MeHg, regulates Se-enhanced antioxidant activity, and decreases MeHg toxicity. Thus, the dietary intake of selenoneine, by consuming fish, might decrease the formation of reactive oxygen radicals that could oxidize nucleotides in DNA, and thereby inhibit carcinogenesis, chronic diseases, and aging.