Menthol cigarettes and risk of lung cancer
Menthol cigarettes and risk of lung cancer
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DOI：
10.1093/aje/kwg182
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发表时间：
2003-10-01
影响因子：
5
通讯作者：
Rosenberg, L
中科院分区：
文献类型：
--
作者：
Brooks, DR;Palmer, JR;Rosenberg, L
作者分析了美国东部一项多医院病例对照研究的数据，以评估吸烟薄荷香烟与吸烟非薄荷香烟相比会增加肺癌风险的假设。研究对象包括肺癌患者和因吸烟无关疾病入院的对照组，他们年龄在40-74岁之间，在1981-2000年间接受了访谈，并且吸烟年限大于或等于20年。关于最近和最长时间吸烟的香烟的品牌和类型的信息。分析基于643例病例和41110名对照，他们的品牌信息超过或等于总吸烟期的60%。根据使用薄荷醇香烟的年数(>；15年，1-15年，0)，调整人口统计学和吸烟相关因素，使用Logistic回归估计肺癌的相对风险。长期吸食薄荷醇香烟者患肺癌的风险与吸食非薄荷醇香烟者相似(优势比=0.97，95%可信区间：0.70，1.34)。在对男性、女性、黑人和白人受试者的单独分析中，优势比也接近1.0。这项研究的结果不支持这样的假设，即吸烟薄荷醇香烟比吸烟非薄荷醇香烟增加患肺癌的风险。
The authors analyzed data from a multihospital case-control study in the eastern United States to evaluate the hypothesis that smoking menthol cigarettes increases lung cancer risk compared with smoking nonmenthol cigarettes. Subjects included cases with lung cancer and controls admitted for conditions unrelated to smoking who were aged 40-74 years, were interviewed from 1981 to 2000, and had smoked for greater than or equal to20 years. Information was available on the brand and type of cigarette smoked most recently and for the longest time. Analyses were based on 643 cases and 4,1110 controls for whom brand information was available for greater than or equal to60% of the total duration of smoking. Logistic regression was used to estimate the relative risk of lung cancer according to number of years of menthol cigarette use (>15, 1-15, 0), adjusting for demographic and smoking-related factors. The lung cancer risk for long-term smokers of menthol cigarettes was similar to that for smokers of nonmenthol cigarettes (odds ratio = 0.97, 95% confidence interval: 0.70, 1.34). Odds ratios were also close to 1.0 in separate analyses of male, female, Black, and White subjects. The results of this study do not support the hypothesis that smoking menthol cigarettes increases the risk of lung cancer relative to smoking nonmenthol cigarettes.