Forward-viewing estimation of 3D blood flow velocity fields by intravascular ultrasound: Influence of the catheter on velocity estimation in stenoses.
Forward-viewing estimation of 3D blood flow velocity fields by intravascular ultrasound: Influence of the catheter on velocity estimation in stenoses.
复制标题
DOI：
10.1016/j.ultras.2021.106558
复制
发表时间：
2021-12
期刊：
影响因子：
4.2
通讯作者：
Lindsey BD
中科院分区：
文献类型：
--
作者：
Kim S;Jing B;Lindsey BD
冠状动脉疾病是最常见的心血管疾病，影响了1800万成年人，仅在美国每年就有36.5万人死亡。壁剪切应力（WSS）是冠状动脉疾病斑块破裂可能性的一个新兴指标，然而，由于在存在明显心脏运动的情况下，在深穿透深度下需要高空间分辨率，因此对三维血流速度和WSS的无创估计具有挑战性。因此，我们提出了一种基于导管的三维血管内前视超声（FV US）换能器的微创成像技术，并提出了一些实验来量化导管对狭窄血管幻象中血流干扰的影响，这些血管幻象具有真实的外周动脉（6.33 mm）和冠状动脉（4.74 mm）的流速和管径。在导管几何形状、管腔直径和导管相对于狭窄位置的不同条件下，通过粒子成像测速（PIV）方法，以每秒5000帧的帧率，使用外部线性阵列超声换能器量化血管模型中的二维速度场。相对于没有导管的情况，实心导管导致的速度测量低估了bbb20 %，而空心导管导致的速度高估< 10%，这表明允许内部血液流动的空心导管设计减少了血流动力学干扰。此外，对于外周动脉和冠状动脉，与对照组相比，空心导管在最小管腔区域的流速偏差< 3%。最后，对使用基于导管的低频3d血管内FV US换能器和外部线性阵列测量的速度进行了初步比较，在150ml /min流速下，整个感兴趣区域的相对误差< 12%。虽然需要进一步的系统开发，但结果表明，通过适当的导管设计，血管内超声表征狭窄血管中的血流速度场是可行的。
Coronary artery disease is the most common type of cardiovascular disease, affecting > 18 million adults, and is responsible for >365k deaths per year in the U.S. alone. Wall shear stress (WSS) is an emerging indicator of likelihood of plaque rupture in coronary artery disease, however, non-invasive estimation of 3-D blood flow velocity and WSS is challenging due to the requirement for high spatial resolution at deep penetration depths in the presence of significant cardiac motion. Thus we propose minimally-invasive imaging with a catheter-based, 3-D intravascular forward-viewing ultrasound (FV US) transducer and present experiments to quantify the effect of the catheter on flow disturbance in stenotic vessel phantoms with realistic velocities and luminal diameters for both peripheral (6.33 mm) and coronary (4.74 mm) arteries. An external linear array ultrasound transducer was used to quantify 2-D velocity fields in vessel phantoms under various conditions of catheter geometry, luminal diameter, and position of the catheter relative to the stenosis at a frame rate of 5000 frames per second via a particle imaging velocimetry (PIV) approach. While a solid catheter introduced an underestimation of velocity measurement by > 20% relative to the case without a catheter, the hollow catheter introduced < 10% velocity overestimation, indicating that a hollow catheter design allowing internal blood flow reduces hemodynamic disturbance. In addition, for both peripheral and coronary arteries, the hollow catheter introduced < 3% deviation in flow velocity at the minimum luminal area compared to the control case. Finally, an initial comparison was made between velocity measurements acquired using a low frequency, catheter-based, 3-D intravascular FV US transducer and external linear array measurements, with relative error < 12% throughout the region of interest for a flow rate of 150 mL/min. While further system development is required, results suggest intravascular ultrasound characterization of blood flow velocity fields in stenotic vessels could be feasible with appropriate catheter design.
登录
查看更多内容
影响因子：
10.6
作者：
Demene, Charlie;Deffieux, Thomas;Tanter, Mickael
通讯作者：
Tanter, Mickael
影响因子：
24
作者：
Fihn, Stephan D.;Gardin, Julius M.;Yancy, Clyde W.
通讯作者：
Yancy, Clyde W.
影响因子：
3.5
作者：
Gerhard-Herman, Marie;Gardin, Julius M.;Naqvi, Tasneem Z.
通讯作者：
Naqvi, Tasneem Z.
影响因子：
3.3
作者：
Aizawa, Kunihiko;Sbragi, Sara;Palombo, Carlo
通讯作者：
Palombo, Carlo
影响因子：
4.8
作者：
BERGELSON, BA;TOMMASO, CL
通讯作者：
TOMMASO, CL