Radiotherapy and Immunogenic Cell Death
Radiotherapy and Immunogenic Cell Death
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DOI：
10.1016/j.semradonc.2014.07.005
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发表时间：
2015-01-01
影响因子：
3.5
通讯作者：
Apetoh, Lionel
中科院分区：
文献类型：
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作者：
Golden, Encouse B.;Apetoh, Lionel
在理解辐射引起的免疫反应和肿瘤消退之间相互作用的机制方面正在取得进展。局部放疗作为免疫佐剂的新兴应用为放射肿瘤学家提供了一种将恶性细胞转化为内源性抗癌疫苗的方法。放射治疗诱导的免疫刺激性肿瘤抗原从垂死的肿瘤细胞释放到周围环境中的分散（称为免疫原性细胞死亡，图1）是一个有助于抗肿瘤免疫传播的可利用过程。免疫系统的下游成分可能抑制、促进或模糊地影响抗肿瘤反应。此外，宿主、肿瘤和治疗相关特征决定了这些信号的重要性，从而决定了治疗结果。在此，我们回顾了放射治疗诱导的免疫原性细胞死亡的过程及其在产生原位疫苗中的作用，以帮助完善基于放射免疫治疗的方案。(C)2015作者爱思唯尔公司出版
Advances in understanding the mechanisms that underlie the interplay between radiation-invoked immune responses and tumor regression are underway. Emerging applications of local radiotherapy as an immunologic adjuvant have provided radiation oncologists with a method for converting malignant cells into endogenous anticancer vaccines. The dispersion of radiotherapy-induced immune-stimulating tumor antigens released from dying tumor cells into the surrounding milieu (known as immunogenic cell death, Fig. 1), is one such exploitable process that contributes to the propagation of antitumor immunity. Downstream components of the immune system may suppress, promote, or ambiguously affect antitumoral responses. Additionally, host, tumor, and treatment-related characteristics govern the significance of these signals, thereby dictating therapeutic outcomes. Herein, we review the process of radiotherapy-induced immunogenic cell death and its role in generating an in situ vaccine to help refine radioimmunotherapy-based protocols. (C) 2015 The Authors. Published by Elsevier Inc.