INTERFERON-GAMMA REGULATION OF INTERLEUKIN-6 IN MONOCYTIC CELLS
INTERFERON-GAMMA REGULATION OF INTERLEUKIN-6 IN MONOCYTIC CELLS
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DOI：
10.1152/ajplung.1994.267.5.l564
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发表时间：
1994-11-01
影响因子：
4.9
通讯作者：
IWAMOTO, GK
中科院分区：
文献类型：
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作者：
BIONDILLO, DE;KONICEK, SA;IWAMOTO, GK
白细胞介素 6 (IL-6) 的调节取决于许多因素，包括脂多糖 (LPS)、病毒和其他细胞因子等多种刺激。这些研究证明，干扰素-γ (IFN-gamma) 能够显着增强 LPS 刺激的单核细胞和 THP-1 细胞中 IL-6 mRNA 和蛋白质的产生。添加 IFN-γ 后，LPS 刺激的细胞中 IL-6 蛋白的产量增加了七倍。添加 IFN-γ 后，LPS 刺激的细胞中 IL-6 mRNA 的产量以剂量依赖性方式增加高达 15 倍。向 LPS 刺激的单核细胞中添加 IFN-γ 后，IL-6 mRNA 的产生增强，这是由于 IL-6 mRNA 的转录增加。 IFN-γ 增强 IL-6 产生的能力可能在许多炎症过程中发挥重要作用。
The regulation of interleukin 6 (IL-6) is dependent on many factors that include numerous stimuli such as lipopolysaccharide (LPS), viruses, and other cytokines. These studies demonstrate the ability of interferon-gamma (IFN-gamma) to significantly enhance IL-6 mRNA and protein production in LPS-stimulated monocytes and THP-1 cells. IL-6 protein production was increased sevenfold in LPS-stimulated cells with the addition of IFN-gamma. IL-6 mRNA production was increased in a dose-dependent fashion up to 15-fold in LPS-stimulated cells with the addition of IFN-gamma. The enhanced production of IL-6 mRNA that occurs with the addition of IFN-gamma to LPS-stimulated monocytic cells was due to increased transcription of IL-6 mRNA. The ability of IFN-gamma to enhance IL-6 production may play an important role in many inflammatory processes.