Intracranial Electroencephalography Reveals Different Temporal Profiles for Dorsal- and Ventro-lateral Prefrontal Cortex in Preparing to Stop Action
Intracranial Electroencephalography Reveals Different Temporal Profiles for Dorsal- and Ventro-lateral Prefrontal Cortex in Preparing to Stop Action
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DOI：
10.1093/cercor/bhs245
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发表时间：
2013-10-01
期刊：
影响因子：
3.7
通讯作者：
Aron, Adam R.
中科院分区：
文献类型：
--
作者：
Swann, Nicole C.;Tandon, Nitin;Aron, Adam R.
准备停止不适当的行为需要牢记任务目标并利用它来影响行为控制系统。我们测试了这样的假设：前额叶皮层的不同子区域显示出不同的时间分布，与准备停止的可分离贡献一致，其中背外侧前额叶皮层（DLPFC）代表任务目标，腹外侧前额叶皮层（VLPFC）执行动作控制。使用从右侧额叶皮层的硬膜下网格记录的皮层电图记录仪对五名人类受试者进行了研究。在每次试验中，任务提示指示受试者是否需要停止（也许停止[MS]或不停止[NS]），然后是继续提示，在一些MS试验中，随后是停止信号。我们专注于 go 试验，比较 MS 和 NS。在 DLPFC 中，大多数受试者在任务提示和执行提示后的高伽马活动有所增加。相比之下，在 MS 试验中，VLPFC 中所有受试者在接近运动反应时间的 go 提示后都有活动，与行为减慢相关，并且明显晚于 DLPFC 活动。这些不同的时间分布表明 DLPFC 和 VLPFC 可能具有分离的角色，其中 DLPFC 代表任务目标，VLPFC 执行动作控制。
Preparing to stop an inappropriate action requires keeping in mind the task goal and using this to influence the action control system. We tested the hypothesis that different subregions of prefrontal cortex show different temporal profiles consistent with dissociable contributions to preparing-to-stop, with dorsolateral prefrontal cortex (DLPFC) representing the task goal and ventrolateral prefrontal cortex (VLPFC) implementing action control. Five human subjects were studied using electrocorticography recorded from subdural grids over right lateral frontal cortex. On each trial, a task cue instructed the subject whether stopping might be needed or not (Maybe Stop [MS] or No Stop [NS]), followed by a go cue, and on some MS trials, a subsequent stop signal. We focused on go trials, comparing MS with NS. In the DLPFC, most subjects had an increase in high gamma activity following the task cue and the go cue. In contrast, in the VLPFC, all subjects had activity after the go cue near the time of the motor response on MS trials, related to behavioral slowing, and significantly later than the DLPFC activity. These different temporal profiles suggest that DLPFC and VLPFC could have dissociable roles, with DLPFC representing task goals and VLPFC implementing action control.