Pyrazolylborate-zinc-nucleobase-complexes, 2:(1) preparations and structures of Tp(Cum,Me)Zn and Tp(Ph,Me)Zn complexes.
Pyrazolylborate-zinc-nucleobase-complexes, 2:(1) preparations and structures of Tp(Cum,Me)Zn and Tp(Ph,Me)Zn complexes.
复制标题
DOI：
10.1021/ic020280e
复制
发表时间：
2002-10
影响因子：
4.6
通讯作者：
Dirk Badura;H. Vahrenkamp
中科院分区：
文献类型：
--
作者：
Dirk Badura;H. Vahrenkamp
本文研究了吡唑硼酸锌配合物Tp（Cum，Me）Zn-碱和Tp（Ph，Me）Zn-碱中9种最重要的核碱基（胸腺嘧啶、尿嘧啶、二氢尿嘧啶、胞嘧啶、腺嘌呤、鸟嘌呤、二氨基嘌呤、黄嘌呤、次黄嘌呤）与锌的相互作用。除鸟嘌呤外，在所有情况下都可以分离出Tp* Zn-碱配合物。可以对八种产品类型中的七种进行结构测定。除了二氢尿嘧啶和黄嘌呤外，锌离子与核苷中带有糖部分的碱基的氮相连。在固态下，所有锌结合的核碱基都参与氢键相互作用。除了黄嘌呤，这包括跨越晶体学反转中心的同源碱基配对。
The interactions of the nine most significant nucleobases (thymine, uracil, dihydrouracil, cytosine, adenine, guanine, diaminopurine, xanthine, hypoxanthine, in their deprotonated forms) with zinc and with themselves in pyrazolylborate zinc complexes Tp(Cum,Me)Zn-base and Tp(Ph,Me)Zn-base are described. Except for guanine, the complexes Tp*Zn-base could be isolated in all cases. Structure determinations could be performed for seven of the eight product types. Except for dihydrouracil and xanthine, the zinc ion is attached to that nitrogen of the base which in nucleosides bears the sugar moiety. In the solid state, all zinc-bound nucleobases are involved in hydrogen bonding interactions. Except for xanthine, this includes homo base pairing across a crystallographic inversion center.