A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence
A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence
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DOI：
10.1111/j.1530-0277.1998.tb03704.x
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发表时间：
1998-08-01
影响因子：
3.2
通讯作者：
Foroud, T
中科院分区：
文献类型：
--
作者：
Edenberg, HJ;Reynolds, J;Foroud, T
最近报道了血清素转运基因（HTT）启动子的调节变异与严重酒精依赖之间的群体关联。我们在美国大量系统确定的家庭中分析了这种潜在的联系；这些家庭至少有三个一级亲属是酒精依赖者。分析的重点是根据ICD-10的标准定义为酒精依赖的个体，以及这些个体中报告戒断相关症状的亚群。传递不平衡检验的应用并没有为这种功能多态性与酒精依赖之间的联系或关联提供支持；这两种等位基因传递给依赖酒精的后代没有明显的偏倚。我们还报道了非洲裔美国人在这种多态性的等位基因频率上与高加索人不同。
A population association between a regulatory variation in the promoter of the serotonin transporter gene (HTT) and severe alcohol dependence was recently reported. We analyzed this potential association in a large number of systematically ascertained families in the United States; these families had at least three first-degree relatives who were alcohol-dependent. Analyses focused on individuals defined as alcohol-dependent by criteria from ICD-10 and on subsets of these individuals reporting withdrawal-related symptoms. Application of the transmission disequilibrium test did not provide support for either linkage or association between this functional polymorphism and alcohol dependence; there was no significant bias in the transmission of either allele to the alcohol-dependent offspring. We also report that African Americans differ from Caucasians in allele frequencies for this polymorphism.