INHIBITION OF FAST AXONAL-TRANSPORT BY ERYTHRO-9-[3-(2-HYDROXYNONYL)]ADENINE
INHIBITION OF FAST AXONAL-TRANSPORT BY ERYTHRO-9-[3-(2-HYDROXYNONYL)]ADENINE
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DOI：
10.1111/j.1471-4159.1984.tb05392.x
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发表时间：
1984-01-01
影响因子：
4.7
通讯作者：
KANJE, M
中科院分区：
文献类型：
--
作者：
EKSTROM, P;KANJE, M
蛋白质羧甲基化和动力蛋白-ATP酶活性抑制剂α-[3-（2-羟基壬基）]腺嘌呤抑制离体蛙坐骨神经的快速轴突运输。其作用部位可能与转运所依赖的ATP酶有关，因为特异性羧甲基化抑制剂对转运缺乏作用。高能磷酸盐和蛋白质合成的水平在运输抑制浓度下不受药物的影响，使得由于代谢效应引起的干扰不太可能。在各种神经片段中寻找一种对α-9-[3-（2-羟基壬基）]腺嘌呤敏感的ATP酶，但迄今尚未解决。
erythro-9-[3-(2-Hydroxynonyl)]adenine, an inhibitor of protein carboxylmethylation and dynein-ATPase activity, inhibited fast axonal transport in vitro in frog sciatic nerves. Its site of action mightl be associated with an ATPase on which transport depends, since specific carboxymethylation inhibitors lacked effects on transport. The levels of high energy phosphates and protein synthesis were unaffected by the drug at a transport-inhibiting concentration, making disturbances due to metabolic effects less likely. An erythro-9-[3-(2-hydroxynonyl)]adenine-sensitive ATPase was looked for in various nerve fractions but has so far not been resolved.