Manipulation of Orthogonal Neural Systems Together in Electrophysiological Recordings: The MONSTER Approach to Simultaneous Assessment of Multiple Neurocognitive Dimensions
Manipulation of Orthogonal Neural Systems Together in Electrophysiological Recordings: The MONSTER Approach to Simultaneous Assessment of Multiple Neurocognitive Dimensions
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DOI：
10.1093/schbul/sbr147
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发表时间：
2012-01-01
影响因子：
6.6
通讯作者：
Luck, Steven J.
中科院分区：
文献类型：
--
作者：
Kappenman, Emily S.;Luck, Steven J.
事件相关电位（ERPs）是理解和评估健康和病理样本的认知、情感、运动和感觉加工的有力工具。一个典型的ERP记录会话需要相当长的时间，但是它被设计成只隔离1-2个组件。尽管这适用于大多数基础科学目的，但对于测量可能在神经或精神疾病中被破坏的广泛的神经认知功能来说，这是一种效率低下的方法。本研究提供了一个框架，通过操作功能正交维度，更有效地评估多个神经过程在一个单一的实验范式。我们描述了一般的MONSTER（在电生理记录中操纵正交神经系统）方法，并解释了它如何适用于研究各种神经认知领域、ERP组件和感兴趣的神经过程。我们还通过提供在较年轻（18-30岁）和较年长（65-85岁）成人样本中实施MONSTER方法的数据，展示了该方法如何用于评估组间差异。MONSTER框架的具体实现评估了视觉领域的4个独立的神经过程：(1)早期感觉处理，使用Cl波；(2)隐性注意转移，具有N2pc分量；(3)分类，用P3分量；(4)自我监控，具有错误相关的负性。虽然MONSTER方法主要是在ERP实验的背景下描述的，但它也可以很容易地用于功能磁共振成像。
Event-related potentials (ERPs) are a powerful tool in understanding and evaluating cognitive, affective, motor, and sensory processing in both healthy and pathological samples. A typical ERP recording session takes considerable time but is designed to isolate only 1-2 components. Although this is appropriate for most basic science purposes, it is an inefficient approach for measuring the broad set of neurocognitive functions that may be disrupted in a neurological or psychiatric disease. The present study provides a framework for more efficiently evaluating multiple neural processes in a single experimental paradigm through the manipulation of functionally orthogonal dimensions. We describe the general MONSTER (Manipulation of Orthogonal Neural Systems Together in Electrophysiological Recordings) approach and explain how it can be adapted to investigate a variety of neurocognitive domains, ERP components, and neural processes of interest. We also demonstrate how this approach can be used to assess group differences by providing data from an implementation of the MONSTER approach in younger (18-30 y of age) and older (65-85 y of age) adult samples. This specific implementation of the MONSTER framework assesses 4 separate neural processes in the visual domain: (1) early sensory processing, using the Cl wave; (2) shifts of covert attention, with the N2pc component; (3) categorization, with the P3 component; and (4) self-monitoring, with the error-related negativity. Although the MONSTER approach is primarily described in the context of ERP experiments, it could also lie adapted easily for use with functional magnetic resonance imaging.