ROLE OF INSULIN-LIKE GROWTH-FACTORS IN EMBRYONIC AND POSTNATAL-GROWTH
ROLE OF INSULIN-LIKE GROWTH-FACTORS IN EMBRYONIC AND POSTNATAL-GROWTH
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DOI：
10.1016/0092-8674(93)90680-o
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发表时间：
1993-10-08
期刊：
影响因子：
64.5
通讯作者：
EFSTRATIADIS, A
中科院分区：
文献类型：
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作者：
BAKER, J;LIU, JP;EFSTRATIADIS, A
对携带编码胰岛素样生长因子I（IGF-I）、IGF-II和1型IGF受体（IGF 1 R）的基因（单独或组合）无效突变的小鼠胚胎的生长动力学进行发育分析，确定了导致生长缺陷的突变效应的发生，并表明在胚胎第11.0和12.5天之间，IGF 1 R仅充当IGF-II的体内促有丝分裂信号。从E13.5开始，IGF 1 R与IGF-I和IGF-II相互作用，而IGF-II识别另一种未知受体（XR）。与胚胎本身相反，胎盘生长完全由IGF-II-XR相互作用提供。额外的遗传数据表明，2型IGF/甘露糖6-磷酸受体不太可能是XR的候选者。出生后的生长曲线表明，存活的Igf-1（-/-）突变体，这是不育的，表现出延迟的骨发育，出生后继续增长与野生型同窝仔相比，速度较慢，成为30%的正常体重的成年人。
A developmental analysis of growth kinetics in mouse embryos carrying null mutations of the genes encoding insulin-like growth factor I (IGF-I), IGF-II, and the type 1 IGF receptor (IGF1R), alone or in combination, defined the onset of mutational effects leading to growth deficiency and indicated that between embryonic days 11.0 and 12.5, IGF1R serves only the in vivo mitogenic signaling of IGF-II. From E13.5 onward, IGF1R interacts with both IGF-I and IGF-II, while IGF-II recognizes an additional unknown receptor (XR). In contrast with the embryo proper, placental growth is served exclusively by an IGF-II-XR interaction. Additional genetic data suggested that the type 2 IGF/mannose 6-phosphate receptor is an unlikely candidate for XR. Postnatal growth curves indicated that surviving Igf-1(-/-) mutants, which are infertile and exhibit delayed bone development, continue to grow with a retarded rate after birth in comparison with wild-type littermates and become 30% of normal weight as adults.