Carbon nanohorns as anticancer drug carriers
Carbon nanohorns as anticancer drug carriers
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DOI：
10.1021/mp0500566
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发表时间：
2005-11-01
影响因子：
4.9
通讯作者：
Ijima, Sumio
中科院分区：
文献类型：
--
作者：
Ajima, Kumiko;Yudasaka, Masako;Ijima, Sumio
我们证明了氧化的单壁碳纳米角（SWNHs），一种单壁纳米管，捕获顺铂，一种抗癌剂。我们发现，顺铂的结构保持在SWNH内部，并且顺铂在水性环境中从SWNH缓慢释放。释放的顺铂能有效地终止人类肺癌细胞的生长，而SWNH本身没有这种效果。因此，顺铂掺入的氧化SWNH是一种潜在的药物递送系统。
We demonstrate that oxidized single-wall carbon nanohorns (SWNHs), a type of single-wall nanotube, entrap cisplatin, an anticancer agent. We found that the cisplatin structure was maintained inside the SWNHs and that the cisplatin was slowly released from the SWNHs in aqueous environments. The released cisplatin was effective in terminating the growth of human lung-cancer cells, while the SWNHs themselves had no such effect. Cisplatin-incorporated oxidized SWNHs are thus a potential drug delivery system.