FDG uptake and glucose transporter type 1 expression in lymph nodes of non-small cell lung cancer
FDG uptake and glucose transporter type 1 expression in lymph nodes of non-small cell lung cancer
复制标题
DOI：
10.1016/j.ejso.2006.05.017
复制
发表时间：
2006-11-01
期刊：
影响因子：
3.8
通讯作者：
Kim, S. E.
中科院分区：
文献类型：
--
作者：
Chung, J. -H.;Lee, W. W.;Kim, S. E.
目的：非小细胞肺癌的FDG摄取与葡萄糖转运蛋白1（Glut-1）表达相关。在这里，我们调查了FDG摄取和Glut-1表达之间的直接因果关系，以确定恶性和良性淋巴结（LNs）中Glut-1在FDG摄取中的作用。方法：纳入53例NSCLC患者（男：女= 36：17，年龄= 62.0 +/- 11.8岁）的55例根治性肺切除术。比较术前全身FDG-PET和Glut-1免疫染色结果中LN的最大标准化摄取值（maxSUV）。316例经病理证实的淋巴结中，12.3%（39/316）为恶性淋巴结，且恶性淋巴结中FDG阳性淋巴结与FDG阴性淋巴结大小无差异（15.0 +/- 6.7 mm vs 10.0 +/- 6.1 mm，p > 0.05），或根据肿瘤占据的LN比例（60.0 +/-28.8%vs 39.2 +/-38.4%，p > 0.05），但肿瘤中Glut-1阳性细胞的百分比更高（74.1 +/- 31.8%对22.7 +/-18.7%，p < 0.01）和Glut-1染色强度（3.4 +/- 0.9对1.8 +/- 1.3，p < 0.01）。FDG阴性的恶性淋巴结以胞浆Glut-1表达和腺癌为特征。Glut-1的表达强度与淋巴结的maxSUV值呈显著正相关（p = 0.516，p < 0.05），但与肿瘤中Glut-1阳性细胞的百分比无相关性（r = 0.2072，p > 0.05）。结论：非小细胞肺癌组织中Glut-1的表达与FDG的摄取程度成正比。然而，在良性淋巴结中，Glut-1在淋巴组织增生中的表达与FDG摄取没有相关性，这一发现需要进一步研究。(c)2006爱思唯尔有限公司版权所有。
Aims: FDG uptake in NSCLC is related to glucose transporter type 1 (Glut-1) expression. Here, we investigated the direct causal relationship between FDG uptake and Glut-1 expression to determine the role of Glut-1 in FDG uptake by malignant and benign lymph nodes (LNs).Methods: Fifty-five curative lung resections in 53 NSCLC patients (male:female = 36:17, age = 62.0 +/- 11.8 years) were included. Maximum standardized uptake values (maxSUVs) of LNs in preoperative whole body FDG-PET and Glut-1 immunostaining results were compared.Results: Of 316 pathologically confirmed LNs, 12.3% (39/316) were malignant, and in malignant LNs, FDG positive LNs were no different from FDG negative LNs in terms of size (15.0 +/- 6.7 mm vs 10.0 +/- 6.1 mm, p > 0.05), or in terms of the proportion of LNs occupied by tumor (60.0 +/- 28.8% vs 39.2 +/- 38.4%, p > 0.05), but had greater percentages of Glut-1 positive cells in tumors (74.1 +/- 31.8% vs 22.7 +/- 18.7%, p < 0.01), and Glut-1 staining intensities (3.4 +/- 0.9 vs 1.8 +/- 1.3, p < 0.01). FDG negative malignant LNs featured cytoplasmic Glut-1 expression and adenocarcinoma. Glut-1 staining intensities were found to be significantly correlated with the maxSUVs of malignant LNs (p = 0.516, p < 0.05), but the percentages of Glut-1 positive cells in tumors were not (r = 0.2072, p > 0.05). Analysis of FDG positive benign LNs showed that maxSUV was not correlated with degree of follicular hyperplasia, or Glut-1 expression (p > 0.05).Conclusions: Intense Glut-1 immunoreactivity was found to be proportionally related to the degree of FDG uptake by malignant LNs in NSCLC. However, the finding that Glut-1 expression in lymphoid hyperplasia showed no correlation with FDG uptake in benign LNs requires further investigation. (c) 2006 Elsevier Ltd. All rights reserved.