Comparison of optical coherence tomography and ultrasound biomicroscopy for detection of narrow anterior chamber angles
Comparison of optical coherence tomography and ultrasound biomicroscopy for detection of narrow anterior chamber angles
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DOI：
10.1001/archopht.123.8.1053
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发表时间：
2005-08-01
影响因子：
--
通讯作者：
Smith, SD
中科院分区：
文献类型：
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作者：
Radhakrishnan, S;Goldsmith, J;Smith, SD
目的：评估使用光学相干断层扫描 (OCT) 和超声生物显微镜 (UBM) 定量成像对狭窄前房 (AC) 角进行分类的准确性。设计：观察比较研究。方法：使用 1.3 μm 光源开发高速（4000 次轴向扫描/秒）眼前段 OCT 原型。纳入 17 名正常受试者（17 只眼）和 7 名患有窄角型青光眼的受试者（14 只眼）。所有受试者均接受前房角镜检查、OCT 和 UBM。使用专有处理软件从 OCT 和 UBM 图像中测量定量 AC 角参数（角张开距离、角凹陷面积和小梁虹膜空间面积 [我们定义的新参数]）。主要结果指标：使用图像衍生的 AC 角参数识别窄角的特异性和灵敏度。结果：31 只眼睛中的 8 只被归类为窄角（Shaffer 级）
Objective: To assess the accuracy of classification of narrow anterior chamber (AC) angles using quantitative imaging by optical coherence tomography (OCT) and ultrasound biomicroscopy (UBM).Design: Observational comparative study.Methods: A high-speed (4000 axial scans/s) anterior segment OCT prototype was developed using a 1.3-mu m light source. Seventeen normal subjects (17 eyes) and 7 subjects (14 eyes) with narrow angle glaucoma were enrolled. All subjects underwent gonioscopy, OCT, and UBM. Quantitative AC angle parameters (angle opening distance, angle recess area, and the trabecular-iris space area [a new parameter we have defined]) were measured from OCT and UBM images using proprietary processing software.Main Outcome Measures: Specificity and sensitivity in identifying narrow angles with image-derived AC angle parameters.Results: Eight of 31 eyes were classified as having narrow angles (Shaffer grade