Association of schizophrenia with low maternal body mass index, small size at birth, and thinness during childhood
Association of schizophrenia with low maternal body mass index, small size at birth, and thinness during childhood
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DOI：
10.1001/archpsyc.58.1.48
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发表时间：
2001-01-01
影响因子：
--
通讯作者：
Eriksson, JG
中科院分区：
文献类型：
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作者：
Wahlbeck, K;Forsén, T;Eriksson, JG
背景：早期生活中的营养因素可能导致精神分裂症的神经发育缺陷。本研究探讨了产妇的身体大小，出生时的大小，和儿童的成长对未来的风险schizophrenia.Subjects和方法的影响：这项以人口为基础的队列研究出生在赫尔辛基大学中心医院在赫尔辛基，芬兰，从1924年至1933年。前瞻性的数据从出生和学校的健康记录的7086个人收集和链接到芬兰医院出院Register.Results：精神分裂症或情感障碍已被诊断为114人。较低的怀孕后期母亲体重指数（BMI）增加了风险（比值比[OR]，1.09/kg/m（2）; 95%可信区间[CI]，1.02-1.17）。（OR，1.48/kg; 95% CI，1.03-2.13），出生时矮小（OR，1.12/cm; 95% CI，1.03-1.22），和低胎盘重量（OR，1.22/100 g; 95%CI，1.04-1.43），精神分裂症患者在7 - 15岁年龄段比对照组瘦。在一个联合模型，包括怀孕后期的母亲体重指数，出生时的身体大小，和儿童的体重指数，儿童的体重指数是一个独立的预测精神分裂症，而其他因素表现出衰减effects.Conclusion：指标宫内和儿童期营养不良与精神分裂症的终生风险增加。
Background: Nutritional factors in early life may contribute to the neurodevelopmental deficit in schizophrenia. This study explores the influence of maternal body size, size at birth, and childhood growth on future risk for schizophrenia.Subjects and Methods: This population-based cohort study comprised births at Helsinki University Central Hospital in Helsinki, Finland, from 1924 to 1933. Prospective data from birth and school health records of 7086 individuals were collected and linked to the Finnish Hospital Discharge Register.Results: Schizophrenia or schizoaffective disorder had been diagnosed in 114 individuals. A lower late-pregnancy maternal body mass index (BMI) increased the risk (odds ratio [OR], 1.09 per kilogram/meter(2); 95% confidence interval [CI], 1.02-1.17) for schizophrenia among the offspring, The risk of schizophrenia increased with low birth weight (OR, 1.48 per kilogram; 95% CI, 1.03-2.13), shortness at birth (OR, 1.12 per centimeter; 95% CI, 1.03-1.22), and low placental weight (OR, 1.22 per 100 g; 95% CI, 1.04-1.43), Schizophrenia cases were thinner than comparison subjects from 7 to 15 years of age. In a joint model comprising late-pregnancy maternal BMI, body size at birth, and childhood BMI, childhood BMI was an independent predictor of schizophrenia, whereas other factors exhibited attenuated effects.Conclusion: Indicators of intrauterine and childhood undernutrition are associated with an increased lifetime risk of schizophrenia.