Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention
Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention
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DOI：
10.1111/j.1753-4887.2008.00093.x
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发表时间：
2008-10-01
影响因子：
6.1
通讯作者：
Jurutka, Peter W.
中科院分区：
文献类型：
--
作者：
Haussler, Mark R.;Haussler, Carol A.;Jurutka, Peter W.
人维生素D受体（VDR）是一种关键的核受体，其结合营养来源的配体并发挥有助于骨矿物质稳态、外源性和内源性化合物的解毒、癌症预防和哺乳动物毛发循环的生物效应。配体VDR通过与类维生素A X受体的异源二聚化和辅激活因子或辅抑制因子的募集来调节基因表达。VDR与辅阻遏物hairless（Hr）相互作用以控制毛发周期，这是一种独立于内分泌VDR配体1，25-二羟基维生素D-3的作用。我们报告了新的维生素D受体的饮食配体，包括姜黄素，γ-生育三烯酚，和必需脂肪酸衍生物，可能发挥作用的维生素D受体的生物作用。(C)2008年国际生命科学研究所。
The human vitamin D receptor (VDR) is a key nuclear receptor that binds nutritionally derived ligands and exerts bioeffects that contribute to bone mineral homeostasis, detoxification of exogenous and endogenous compounds, cancer prevention, and mammalian hair cycling. Liganded VDR modulates gene expression via heterodimerization with the retinoid X receptor and recruitment of coactivators or corepressors. VDR interacts with the corepressor hairless (Hr) to control hair cycling, an action independent of the endocrine VDR ligand, 1,25-dihydroxyvitamin D-3. We report novel dietary ligands for VDR including curcumin, gamma-tocotrienol, and essential fatty acid derivatives that likely play a role in the bioactions of VDR. (C) 2008 International Life Sciences Institute.