Biochemical markers of bone turnover as predictors of osteoporosis and osteoporotic fractures in men and women: 10-year follow-up of the Taiji cohort
Biochemical markers of bone turnover as predictors of osteoporosis and osteoporotic fractures in men and women: 10-year follow-up of the Taiji cohort
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DOI：
10.3109/s10165-011-0455-2
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发表时间：
2011-04
影响因子：
2.2
通讯作者：
N. Yoshimura;S. Muraki;H. Oka;H. Kawaguchi;Kozo Nakamura;T. Akune
中科院分区：
文献类型：
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作者：
N. Yoshimura;S. Muraki;H. Oka;H. Kawaguchi;Kozo Nakamura;T. Akune
我们的目的是评估骨转换生化标志物（BTM）预测骨丢失、骨质疏松症（OP）和骨质疏松性骨折的能力。我们从登记的居民名单中随机选择了400人（1993年年龄在40-79岁之间;每个性别和年龄层各50人）。在1993年、1996年、2000年和2003年，通过双能X线吸收法测量脊柱和髋关节的骨矿物质密度（BMD）。基线时评估的BTM包括血清完整骨钙素（OC）、总OC、骨特异性碱性磷酸酶、I型前胶原C端前肽、I型前胶原N端前肽（PINP）、基质金属蛋白酶产生的I型胶原C端交联端肽、I型胶原C端交联端肽（β-CTX）、I型胶原的N-末端交联端肽（NTX）、尿吡啶啉和脱氧吡啶啉（DPD）。对于307例完成者，调整混杂因素后的多变量分析显示，男性血清PINP水平[风险比（HR）2.80，P < 0.05]和男性血清PINP水平[风险比（HR）2.80，P < 0.05]均高于男性[风险比（HR）2.80，P <0.05]。（HR 1.65，P < 0.05），β-CTX（HR 1.80，P < 0.001），NTX（HR 1.96，P < 0.01），尿DPD水平（HR 1.40，P < 0.05）与脊柱OP的发生显著相关。除了校正BMD的基线状态，即，在女性中，骨量减少或正常范围、PINP、β-CTX和NTX可以显著预测未来脊柱OP的发生。BTM不是骨质丢失、股骨OP或骨质疏松性骨折的显著预测因子。总之，女性的各种BTM可以预测脊柱OP的发生。
We aimed to assess the capacity of biochemical markers of bone turnover (BTMs) to predict bone loss, osteoporosis (OP), and osteoporotic fractures. We randomly selected 400 individuals (age 40–79 years in 1993; 50 of each gender and age stratum) from a list of registered residents. In the years 1993, 1996, 2000, and 2003, bone mineral density (BMD) of the spine and hip were measured by dual-energy X-ray absorptiometry. The BTMs assessed at baseline were serum intact osteocalcin (OC), total OC, bone-specific alkaline phosphatase, C-terminal propeptide of type I procollagen, N-terminal propeptide of type I procollagen (PINP), C-terminal cross-linking telopeptide of type I collagen generated by matrix metalloproteinase, C-terminal cross-linking telopeptide of type I collagen (beta-CTX), N-terminal cross-linking telopeptide of type I collagen (NTX), urinary pyridinoline, and deoxypyridinoline (DPD). For 307 completers, multivariate analysis after adjusting for confounders revealed that serum PINP levels in men [hazard ratio (HR) 2.80, P < 0.05] and serum PINP (HR 1.65, P < 0.05), beta-CTX (HR 1.80, P < 0.001), NTX (HR 1.96, P < 0.01), and urinary DPD levels (HR 1.40, P < 0.05) in women were significantly related to the occurrence of spinal OP. In addition to adjustment for the baseline status of BMD, i.e., osteopenia or normal range, PINP, beta-CTX, and NTX in women could significantly predict the future occurrence of spinal OP. BTMs were not significant predictors of bone loss, femoral OP, or osteoporotic fractures. In conclusion, various BTMs in women can predict the occurrence of spinal OP.