Microrheology with optical tweezers: measuring the relative viscosity of solutions 'at a glance'.
Microrheology with optical tweezers: measuring the relative viscosity of solutions 'at a glance'.
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DOI：
10.1038/srep08831
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发表时间：
2015-03-06
影响因子：
4.6
通讯作者：
Cooper JM
中科院分区：
文献类型：
--
作者：
Tassieri M;Del Giudice F;Robertson EJ;Jain N;Fries B;Wilson R;Glidle A;Greco F;Netti PA;Maffettone PL;Bicanic T;Cooper JM
我们提出了一种测量流体相对粘度的简单方法，通过对光学捕获头的归一化位置自相关函数的简单图形分析，而无需进行费力的计算。当采用微流变学方法测量可用性有限的材料时，例如涉及生物学研究的材料，其优点是显而易见的。该方法已通过与传统体流变学方法的直接比较得到验证，并已应用于合成线性聚电解质溶液的表征和生物医学样品的研究。
We present a straightforward method for measuring the relative viscosity of fluids via a simple graphical analysis of the normalised position autocorrelation function of an optically trapped bead, without the need of embarking on laborious calculations. The advantages of the proposed microrheology method are evident when it is adopted for measurements of materials whose availability is limited, such as those involved in biological studies. The method has been validated by direct comparison with conventional bulk rheology methods, and has been applied both to characterise synthetic linear polyelectrolytes solutions and to study biomedical samples.