DEVELOPMENT OF TUBULAR AND GLOMERULAR CELLS OF THE KIDNEY
DEVELOPMENT OF TUBULAR AND GLOMERULAR CELLS OF THE KIDNEY
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DOI：
10.1038/ki.1992.101
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发表时间：
1992-03-01
影响因子：
19.6
通讯作者：
EKBLOM, P
中科院分区：
文献类型：
--
作者：
SOROKIN, L;EKBLOM, P
肾脏的许多功能由两种细胞类型执行，即上皮细胞和内皮细胞。上皮细胞构成远端和近端小管，以及肾小球的内脏（足细胞）和壁（囊）上皮，而内皮细胞包括所有血管系统，也可能产生肾小球的系膜。上皮细胞发育的几个方面最近已经澄清，在过去的十年中，肾脏血管生成的新信息已经变得可用。这些研究也为了解系膜的性质和生物学提供了一些见解[1]。在胚胎发生过程中，身体大多数器官的上皮细胞通过一个称为分支形态发生的过程，通过预先存在的上皮片的延伸形成。集合管和输尿管的上皮细胞通过这样的过程形成[1-4]。然而，肾小管和肾小球内的上皮细胞是例外，它们是由间充质直接转化为上皮细胞形成的[1，5，6]。后一种发育模式使肾脏成为研究上皮细胞极性建立的理想模型，这是通过分支形态发生发育的细胞也共有的发育重要事件。
Many of the functions of the kidney are carried out by two cell types, the epithelial and the endothelial cells. Epithelial cells constitute the distal and proximal tubuli, and the visceral (podocytes) and parietal (capsular) epithelium of the glomeruli, while the endothelial cells comprise all vasculature and possibly also give rise to the mesangium of the glomeruli. Several aspects of epithelial cell development have recently been clarified, and over the past ten years new information on angiogenesis of the kidney has become available. These studies have also provided some insight into the nature and biology of the mesangium [1].During embryogenesis the epithelial cells of most organs of the body form by an extension of a pre-existing epithelial sheet by a process known as branching morphogenesis. The epithelial cells of the collecting ducts and ureter form by such a process [1–4]. The epithelial cells of the kidney tubules and within the glomerulus, however, are exceptions and form by a direct conversion of mesenchyme to epithelium [1, 5, 6]. This latter mode of development renders the kidney an ideal model for studying the establishment of polarity of epithelial cells, a developmentally important event also shared by cells which develop by branching morphogenesis.