Anaphylactic reaction to polyethylene‐glycol conjugated‐asparaginase: Premedication and desensitization may not be sufficient
Anaphylactic reaction to polyethylene‐glycol conjugated‐asparaginase: Premedication and desensitization may not be sufficient
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对聚乙二醇结合天冬酰胺酶的过敏反应：术前用药和脱敏可能还不够
DOI：
10.1111/ped.12131
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发表时间：
2013
影响因子：
1.4
通讯作者：
C. Saçkesen
中科院分区：
文献类型：
--
作者：
U. Sahiner;S. T. Yavuz;M. Gökçe;B. Buyuktiryaki;Ilhan Altan;S. Aytaç;M. Tuncer;A. Tuncer;C. Saçkesen
在对天然L-天冬酰胺酶的超敏反应中，首选的方法是预先用药和脱敏，或用聚乙二醇偶联天冬酰胺酶(PEGASP)替代。使用聚乙二醇-天冬氨酸的过敏反应很少见。1例8岁女孩和1例2.5岁男孩均被诊断为急性淋巴细胞白血病，表现为土生型L天冬酰胺酶过敏，首选用聚乙二醇天冬氨酸氨基转移酶替代。他们接受预先用药(甲基强的松龙、羟基锌和雷尼替丁)，然后用聚乙二醇-天冬氨酸输注脱敏。两名患者都出现了聚乙二胺天冬酰胺酶过敏反应。这是首次报道的对聚乙二醇-天冬氨酸过敏反应的病例，尽管应用了预先用药和脱敏。使用聚乙二醇-天冬氨酸的过敏反应是非常罕见的，前用药和脱敏方案可能无法阻止这些超敏反应。
In hypersensitive reactions to native L‐asparaginase, either premedication and desensitization or substitution with polyethylene glycol conjugated asparaginase (PEG‐ASP) is preferred. Anaphylaxis with PEG‐ASP is rare. An 8‐year‐old girl and a 2.5‐year‐old boy, both diagnosed as having acute lymphoblastic leukemia, presented with native L‐asparaginase hypersensitivity and substitution with PEG‐ASP was preferred. They received a premedication (methylprednisolone, hydroxyzine and ranitidine) followed by desensitization with PEG‐ASP infusion. Both patients developed anaphylaxis with peg‐asparaginase. These are the first reported cases of anaphylactic reaction to PEG‐ASP, despite the application of both premedication and desensitization. Anaphylaxis with PEG‐ASP is very rare and premedication and desensitization protocols may not prevent these hypersensitive reactions.