[M(CO)2(NO)]2+, a new core in bioorganometallic chemistry:: model complexes of Re(CO)2(NO)2+ and [99mTc(CO)2(NO)2+
[M(CO)2(NO)]2+, a new core in bioorganometallic chemistry:: model complexes of Re(CO)2(NO)2+ and [99mTc(CO)2(NO)2+
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DOI：
10.1016/j.tetlet.2004.03.140
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发表时间：
2004-05-17
影响因子：
1.8
通讯作者：
Alberto, R
中科院分区：
文献类型：
--
作者：
Rattat, D;Verbruggen, A;Alberto, R
在本研究中，选择的二齿（L-2）和三齿（L-3）配体与Re（I）或Tc（I）核[M（CO）（2）（NO）]（2-）配位，得到通式为fac-[MX（L-2）（CO）（2）（NO）]和fac-[M（L-3）（CO）（2）（NO）]的配合物（M = Re或Tc：X = Br或Cl）。这些配合物是由[M（CO）（2）（NO）]（2+）直接与配体反应得到的，或先与[M（CO）（3）]（+）反应，再与[NO][BF 4]或[NO][HSO 4]进行亚硝基化得到的。在条件适应n.c.a.之前，大多数反应在宏观水平上用冷菜籽油进行。锝（Tc-99 m）水平。氯化以溴代物和硝酸盐为单齿配体，吡啶甲酸（PIC）为双齿配体，组氨酸（HIS）、亚氨基二乙酸（IDA）和次氮基三乙酸（NTA）为三齿配体。我们合成并描述了双核配合物[ReCl（mu-Cl）（CO）（2）（NO）]（2）和单核配合物[NEt 4][ReCl 3（CO）（2）（NO）]、[NEt 4][ReBr 3（CO）（2）（NO）]、[ReBr（PIC）（CO）（2）（NO）]。[NMe4][Re（NO3）（3）（CO）（2）（NO）]、[Re（HIS）（CO）（2）（NO）][BF 4]、[Tc-99（HIS）（CO）（2）（NO）][BF 4]、[Tc-99m（IDA）（CO）（2）（NO）]和[Tc-99m（NTA）（CO）（2）（NO）]。Re和Tc-二羰基-亚硝酰基配合物的化学和物理特性与相应的三羰基化合物的化学和物理特性显著不同。(C)2004爱思唯尔有限公司保留所有权利。
In this Study selected bidentate (L-2) and tridentate (L-3) ligands were coordinated to the Re(I) or Tc(I) core [M(CO)(2)(NO)](2-) resulting in complexes of the general formula fac-[MX(L-2)(CO)(2)(NO)] and fac-[M(L-3)(CO)(2)(NO)] (M = Re or Tc: X = Br or Cl). The complexes were obtained directly from the reaction of [M(CO)(2)(NO)](2+) with the ligand or indirectly by first reacting the ligand with [M(CO)(3)](+) and subsequent nitrosylation with [NO][BF4] or [NO][HSO4]. Most of the reactions were performed with cold rhenium oil a macroscopic level before the conditions were adapted to the n.c.a. level with technetium (Tc-99m). Chloride. bromide and nitrate were Used as monodentate ligands, picolinic acid (PIC) as a bidentate ligand and histidine (HIS), iminodiacetic acid (IDA) and nitrilotriacetic acid (NTA) as tridentate ligands. We synthesised and describe the dinuclear complex [ReCl(mu-Cl)(CO)(2)(NO)](2) and the mononuclear complexes [NEt4][ReCl3(CO)(2)(NO)], [NEt4][ReBr3(CO)(2)(NO)], [ReBr(PIC)(CO)(2)(NO)]. [NMe4][Re(NO3)(3)(CO)(2)(NO)], [Re(HIS)(CO)(2)(NO)][BF4], [Tc-99(HIS)(CO)(2)(NO)][BF4], [Tc-99m(IDA)(CO)(2) (NO)] and [Tc-99m(NTA)(CO)(2)(NO)]. The chemical and physical characteristics of the Re and Tc-dicarbonyl-nitrosyl complexes differ significantly from those of the corresponding tricarbonyl compounds. (C) 2004 Elsevier Ltd. All rights reserved.