Deriving aquatic PNECs of endocrine disruption effects for PFOS and PFOA by combining species sensitivity weighted distributions and adverse outcome pathway networks.
Deriving aquatic PNECs of endocrine disruption effects for PFOS and PFOA by combining species sensitivity weighted distributions and adverse outcome pathway networks.
复制标题
DOI：
10.1016/j.chemosphere.2023.140583
复制
发表时间：
2023-10
期刊：
影响因子：
8.8
通讯作者：
Jiawei Zhang;Huanyu Tao;Jianghong Shi;Hui Ge;Bin Li;Yunhe Wang;Mengtao Zhang;Xiaoyan Li
中科院分区：
文献类型：
--
作者：
Jiawei Zhang;Huanyu Tao;Jianghong Shi;Hui Ge;Bin Li;Yunhe Wang;Mengtao Zhang;Xiaoyan Li
全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）作为新兴的内分泌干扰物（EDCs），对水生生物具有不利影响。传统的生态风险评估（ERA）没有充分考虑PFOS和PFOA的毒性作用模式，可能会导致对风险的低估和决策者的困惑。在本研究中，我们基于不良结果途径（AOP）网络建立了种属敏感性加权分布（SSWD）模型，用于推导预测的无作用浓度（PNEC）。采用3种加权标准（种内变异、营养级丰度和数据质量）和加权对数正态分布方法。所开发的模型考虑了种间/种内变异和内分泌干扰效应的整合非传统终点。全氟辛烷磺酸和全氟辛酸的内分泌干扰效应预测无效浓度分别为2.52微克/升（95%置信区间为0.667-9.85微克/升）和18.7微克/升（5.40-71.0微克/升），这比SSD方法得出的数值更为保守，与文献中基于慢性毒性数据得出的数值相当。就全氟辛烷磺酸而言，生长和发育的影响最为敏感;而就全氟辛酸而言，在生长和发育、生殖、生物化学和遗传以及生存的影响中，生殖的影响最为敏感。全氟辛烷磺酸和全氟辛酸对内分泌的干扰作用很大，需要在《电子逆向拍卖》中得到充分认识。本研究提供了一个ERA框架，可以提高生态相关性，减少内分泌干扰物的PNEC的不确定性。
Perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), as emerging endocrine-disrupting chemicals (EDCs), pose adverse effects on aquatic organisms. Conventional ecological risk assessment (ERA) not fully considering the mode of toxicity action of PFOS and PFOA, may result in an underestimation of risks and confuse decision-makers. In the study, we developed species sensitivity weighted distribution (SSWD) models based on adverse outcome pathway (AOP) networks for deriving predicted no-effect concentrations (PNECs). Three kinds of weighting criteria (intraspecies variation, trophic level abundance, and data quality) and weighted log-normal distribution methods were adopted. The developed models considered the inter/intraspecies variation and integrated nontraditional endpoints of endocrine-disrupting effects. The PNECs of endocrine disruption effects were derived as 2.52 μg/L (95% confidence intervals 0.667–9.85 μg/L) for PFOS and 18.7 μg/L (5.40–71.0 μg/L) for PFOA, which were more conservative than those derived from the SSD method and were comparable with the values in the literature based on the chronic toxicity data. For PFOS, the effect of growth and development was the most sensitive; however, for PFOA, the effect of reproduction was the most sensitive in the effects of growth and development, reproduction, biochemistry and genetics, and survival. The endocrine-disrupting effects of PFOS and PFOA are significant and need to be fully recognized in the ERA. This study provided an ERA framework that can improve the ecological relevance and reduce the uncertainty of PNECs of EDCs.