Nociceptive behavior induced by mustard oil injection into the temporomandibular joint is blocked by a peripheral non-opioid analgesic and a central opioid analgesic
Nociceptive behavior induced by mustard oil injection into the temporomandibular joint is blocked by a peripheral non-opioid analgesic and a central opioid analgesic
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DOI：
10.1016/j.pbb.2008.08.001
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发表时间：
2009-01-01
影响因子：
3.6
通讯作者：
de Arruda Veiga, Maria Cecilia Ferraz
中科院分区：
文献类型：
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作者：
Bonjardim, Leonardo Rigoldi;da Silva, Adriana Pelegrini;de Arruda Veiga, Maria Cecilia Ferraz
本研究旨在改进芥子油（MO）诱导的大鼠颞下颌关节（TMJ）伤害性反应模型，并探讨全身性安乃近和曲马多对低浓度MO诱导的大鼠TMJ伤害性行为反应的潜在镇痛作用。颞下颌关节注射2.5%MO可产生明显的头部退缩和摩擦口面的伤害性行为。该活性与MO注射相关，因为矿物油（溶剂）未引起反应。局部应用利多卡因N-乙基溴季盐，QX-314（2%）和全身给予吗啡（4 mg/kg）显着降低MO诱导的伤害性反应，验证了行为的伤害性特征。预先全身给予安乃近（19、57或95 mg/kg）和曲马多（5、7.5或10 mg/kg）可有效降低颞下颌关节注射MO引起的伤害性行为反应。总之，TMJ注射低浓度的MO在大鼠中产生明确的和可量化的伤害性行为，构成一个可靠的行为模型，用于研究TMJ疼痛机制和测试镇痛药物。结果还表明，安乃近和曲马多可能是有效的止痛剂的选择，在颞下颌关节疼痛的管理。(c)2008年爱思唯尔公司All rights reserved.
The aim of this study was to improve the mustard oil (MO) induced temporomandibular joint (TMJ) nociception model and to investigate the potential analgesic activity of systemic dipyrone and tramadol on the nociceptive behavioral responses induced by injection of low concentrations of the MO into the rat TMJ region. TMJ injection of 2.5% MO produced a significant nociceptive behavior expressed by head flinching and orofacial rubbing. This activity was related to the MO injection since mineral oil (vehicle) did not elicit response. Local application of the lidocaine N-ethyl bromide quaternary salt, QX-314 (2%) and systemic administration of morphine (4 mg/kg) significantly reduced the MO-induced nociceptive responses, validating the nociceptive character of the behaviors. The pretreatment with systemic dipyrone (19, 57 or 95 mg/kg) as well as tramadol (5, 7.5 or 10 mg/kg) was effective in decreasing the nociceptive behavioral responses induced by the injection of MO into the rat TMJ. In conclusion, TMJ injection of low concentrations of MO in rats produces well defined and quantifiable nociceptive behaviors constituting a reliable behavioral model for studying TMJ pain mechanisms and testing analgesic drugs. The results also suggest that dipyrone and tramadol could be effective analgesic options in the management of TMJ pain. (c) 2008 Elsevier Inc. All rights reserved.