A RANDOM-WALK GIANT-LOOP MODEL FOR INTERPHASE CHROMOSOMES
A RANDOM-WALK GIANT-LOOP MODEL FOR INTERPHASE CHROMOSOMES
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DOI：
10.1073/pnas.92.7.2710
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发表时间：
1995-03-28
影响因子：
11.1
通讯作者：
HEARST, JE
中科院分区：
文献类型：
--
作者：
SACHS, RK;VANDENENGH, G;HEARST, JE
荧光原位杂交数据之间的距离定义的基因组序列被用来构建一个定量模型的整体几何结构的人类染色体。我们认为，在细胞周期的G（0）/G（1）部分的大规模的几何形状可能包括灵活的染色质环，平均约300万bp，与随机行走的骨干。一个完全明确的，三参数的聚合物模型，这种无规行走/巨环结构可以很好地解释的数据，更一般的模型与数据一致的简要讨论。
Fluorescence in situ hybridization data on distances between defined genomic sequences are used to construct a quantitative model for the overall geometric structure of a human chromosome. We suggest that the large-scale geometry during the G(0)/G(1) part of the cell cycle may consist of flexible chromatin loops, averaging approximate to 3 million bp, with a random-walk backbone. A fully explicit, three-parametric polymer model of this random-walk/giant-loop structure can account well for the data, More general models consistent with the data are briefly discussed.