Glutathione-Induced Intracellular Release of Guests from Mesoporous Silica Nanocontainers with Cyclodextrin Gatekeepers
Glutathione-Induced Intracellular Release of Guests from Mesoporous Silica Nanocontainers with Cyclodextrin Gatekeepers
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DOI：
10.1002/adma.201001417
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发表时间：
2010-10-08
影响因子：
29.4
通讯作者：
Kim, Chulhee
中科院分区：
文献类型：
--
作者：
Kim, Hyehyeon;Kim, Saehee;Kim, Chulhee
环糊精通过二硫键连接到介孔二氧化硅纳米颗粒上是有效的看门人，不仅可以将客体分子捕获在孔中，而且可以响应谷胱甘肽（GSH）释放客体。PEG化的纳米容器还在癌细胞中表现出有效的GSH介导的多柔比星释放。我们的方法为多功能输送系统提供了独特的应用。
Cyclodextrins tethered onto a mesoporous silica nanoparticle via disulfide stalking are effective gatekeepers not only to entrap guest molecules in the pore but also to release the guest in response to glutathione (GSH). The PEGylated nanocontainers also exhibit efficient GSH-mediated release of doxorubicin in cancer cells. Our approach offers unique applications for multifunctional delivery systems.