Silver nanoparticles in dentistry
Silver nanoparticles in dentistry
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DOI：
10.1016/j.dental.2017.07.002
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发表时间：
2017-10-01
期刊：
影响因子：
5
通讯作者：
Duran, Nelson
中科院分区：
文献类型：
--
作者：
Noronha, Victor T.;Paula, Amauri J.;Duran, Nelson
目标。银纳米粒子(AgNPs)因其抗菌性能而被广泛研究，在牙科领域具有广泛的应用前景。由于人们对AgNPs的兴趣与日俱增，本文的目的是综述它们在纳米复合材料、种植体涂层、具有抗龋菌活性的预制剂、牙周生物膜、真菌病原体和牙髓细菌以及其他应用方面的应用，如口腔癌症的治疗和局部麻醉。并对其作用机制和最重要的毒理学方面的最新研究成果进行了综述。计算机检索Web of Science(ISI)、Google、PubMed、SciFinder和Espace enet数据库，检索词分别为“银纳米*或银纳米粒*”和“牙科医生*或牙科*或牙本质”，检索词为“银纳米*或银纳米银*”。共审查了155篇同行评议的文章。其中大部分是在2012-2017年间发表的，表明这一主题目前代表了牙科研究的一个重要趋势。体外研究表明，AgNPs与牙科材料如纳米复合材料、丙烯酸树脂、树脂共聚单体、粘合剂、根管内药物和种植体涂层联合使用时，具有良好的抗菌活性。此外，由于其抗肿瘤特性，AgNPs被证明是治疗口腔癌的有趣工具。文献表明，AgNPs具有抗菌、抗炎和抗肿瘤等重要功能，是一种很有前途的系统，也是一种潜在的药物缓释载体。然而，AgNPs的作用机制的某些方面，以及使用该系统所产生的一些重要的毒理学方面必须完全阐明。(C)2017年牙科材料学院。爱思唯尔有限公司出版。保留所有权利。
Objective. Silver nanoparticles (AgNPs) have been extensively studied for their antimicrobial properties, which provide an extensive applicability in dentistry. Because of this increasing interest in AgNPs, the objective of this paper was to review their use in nanocomposites; implant coatings; pre-formulation with antimicrobial activity against cariogenic pathogens, periodontal biofilm, fungal pathogens and endodontic bacteria; and other applications such as treatment of oral cancer and local anesthesia. Recent achievements in the study of the mechanism of action and the most important toxicological aspects are also presented.Methods. Systematic searches were carried out in Web of Science (ISI), Google, PubMed, SciFinder and EspaceNet databases with the keywords "silver nano* or AgNP*" and "dentist* or dental* or odontol*".Results. A total of 155 peer-reviewed articles were reviewed. Most of them were published in the period of 2012-2017, demonstrating that this topic currently represents an important trend in dentistry research. In vitro studies reveal the excellent antimicrobial activity of AgNPs when associated with dental materials such as nanocomposites, acrylic resins, resin co-monomers, adhesives, intracanal medication, and implant coatings. Moreover, AgNPs were demonstrated to be interesting tools in the treatment of oral cancers due to their antitumor properties.Signcance. The literature indicates that AgNPs are a promising system with important features such as antimicrobial, anti-inflammatory and antitumor activity, and a potential carrier in sustained drug delivery. However, there are some aspects of the mechanisms of action of AgNPs, and some important toxicological aspects arising from the use of this system that must be completely elucidated. (C) 2017 The Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.