Hormone receptors in mammary gland and the mechanisms of hormone action at the cellular level.
Hormone receptors in mammary gland and the mechanisms of hormone action at the cellular level.
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乳腺激素受体和细胞水平激素作用机制。
DOI：
10.1007/978-3-642-81389-4_6
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发表时间：
1980
影响因子：
2.7
通讯作者：
I. Hart
中科院分区：
文献类型：
--
作者：
A. T. Cowie;I. Forsyth;I. Hart
乳腺是类固醇和多肽激素的靶组织，但我们对这些激素如何向乳腺细胞传递信息（指导增殖、分化和控制乳汁合成和分泌）仍然知之甚少。激素与其靶组织之间的相互作用由位于膜、胞质溶胶或细胞核中的激素特异性结合位点介导。这是一个积极研究和迅速发展的领域，并不断受到审查。对研究的大部分刺激，特别是关于类固醇激素与乳腺组织结合的研究，来自于乳腺癌临床评估中的潜在应用（参见McGuire等人，1977年）。对大鼠乳腺肿瘤也进行了广泛研究（见Leung，1978）。然而，这项工作超出了本书的范围，只有在它反映了正常乳腺的功能时才会提到。
The mammary gland is a target tissue for steroid and polypeptide hormones, but we still know relatively little about how these hormones deliver their messages (directing proliferation, differentiation and the control of milk synthesis and secretion) to the mammary cells. Interaction between a hormone and its target tissue is mediated by hormone-specific binding sites located in membranes, cytosol or nuclei. This is an area of active research and rapid development, and is under constant review. Much of the stimulus to research, particularly on steroid hormone binding to mammary tissue, has come from potential applications in clinical assessment of breast cancer (see McGuire et al., 1977). Mammary tumours in the rat have also been extensively studied (see Leung, 1978). This work is, however, outside the scope of this book and will be referred to only where it reflects on the function of normal mammary gland.