Antibacterial activity of reduced iron clay against pathogenic bacteria associated with wound infections
Antibacterial activity of reduced iron clay against pathogenic bacteria associated with wound infections
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DOI：
10.1016/j.ijantimicag.2018.07.018
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发表时间：
2018-11-01
影响因子：
10.8
通讯作者：
Patel, Robin
中科院分区：
文献类型：
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作者：
Caflisch, Katherine M.;Schmidt-Malan, Suzannah M.;Patel, Robin
粘土是当地文化历史上用来治疗浅表伤口感染的物质。这项研究评估了一种新近发现的粘土-OMT蓝色粘土-对葡萄球菌、链球菌、肠杆菌科细菌和非发酵革兰氏阴性杆菌的作用。在生物膜和浮游状态下，对粘土及其含水渗滤液的抗细菌作用进行了评估。消磨时间的研究被用来评估浮游活动。医用级聚四氟乙烯圆盘上的生物膜用水合粘土悬浮液或渗滤液处理。在浮游研究中，粘土和渗滤液对所有测试菌株都显示出杀菌活性，但渗滤液对金黄色葡萄球菌IDRL-6169和USA300除外。除金黄色葡萄球菌IDRL-6169和USA300外，用粘土悬浮液和渗滤液处理的所有菌株的生物被膜数量与对照相比均显著减少(P
Clay is a substance historically utilized by indigenous cultures for the treatment of superficial wound infections. This study evaluated the effects of a recently identified clay - OMT Blue Clay - against staphylococci, streptococci, Enterobacteriaceae and non-fermenting Gram-negative bacilli. The clay and its aqueous leachate were evaluated against the bacteria in biofilm and planktonic states. Time-kill studies were used to assess planktonic activity. Biofilms on medical-grade Teflon discs were treated with a hydrated clay suspension or leachate. For the planktonic studies, clay and leachate exhibited bactericidal activity against all strains tested, with the exception of leachate against Staphylococcus aureus IDRL-6169 and USA300. All strains treated with clay suspension and leachate resulted in statistically significant biofilm population reductions compared with controls, except S. aureus IDRL-6169 and USA300 (P