EFFECT OF REPEATED TREATMENT WITH DESIPRAMINE IN THE BEHAVIORAL DESPAIR TEST IN RATS - ANTAGONISM BY ATYPICAL BUT NOT CLASSICAL NEUROLEPTICS OR ANTIADRENERGIC DRUGS
EFFECT OF REPEATED TREATMENT WITH DESIPRAMINE IN THE BEHAVIORAL DESPAIR TEST IN RATS - ANTAGONISM BY ATYPICAL BUT NOT CLASSICAL NEUROLEPTICS OR ANTIADRENERGIC DRUGS
复制标题
DOI：
10.1016/0024-3205(84)90089-4
复制
发表时间：
1984-01-01
期刊：
影响因子：
6.1
通讯作者：
SAMANIN, R
中科院分区：
文献类型：
--
作者：
BORSINI, F;NOWAKOWSKA, E;SAMANIN, R
地塞帕明每天20 mg/kg，连续7天给药可减少大鼠在行为绝望实验中的不动时间。舒必利(100 mg/kg)、胃复安(20 mg/kg)可拮抗DMI的作用。和氯丙嗪(20 mg/kg ip)。而不是氟哌啶醇(0.5 mg/kg ip)。或氯丙嗪(5 mg/kg ip)。α-肾上腺素受体阻滞剂(哌唑嗪3 mg/kg S.C.；安非他酮10 mg/kg I.P.；氮杂西汀24 mg/kg S.C.；酚妥拉明20 mg/kg I.P.)，dl-心得安(5 mg/kg I.P.)可乐定(0.1 mg/kg ip)。修改DMI的反固定效果失败。显然，在大鼠的行为绝望测试中，一个特定的多巴胺受体亚型参与了用DMI治疗7天的抗不动效应。
A 7-day treatment with 20 mg/kg per day desipramine [DMI] reduced the immobility time in the behavioral despair test in rats. The effect of DMI was antagonized by sulpiride (100 mg/kg i.p.), metoclopramide (20 mg/kg i.p.) and clopazine (20 mg/kg i.p.) but not by haloperidol (0.5 mg/kg i.p.) or chlorpromazine (5 mg/kg i.p.). .alpha.-Adrenoreceptor blockers (prazosin 3 mg/kg s.c.; aceperone 10 mg/kg i.p.; azapetine 24 mg/kg s.c.; phentolamine 20 mg/kg i.p.), dl-propranolol (5 mg/kg i.p.) and clonidine (0.1 mg/kg i.p.) failed to modify the anti-immobility effect of DMI. Apparently, a particular subtype of dopamine receptors is involved in the anti-immobility effect of a 7-day treatment with DMI in the behavioral despair test in rats.