Characterising private and shared signatures of positive selection in 37 Asian populations
Characterising private and shared signatures of positive selection in 37 Asian populations
复制标题
描述 37 个亚洲人群的私人和共同的积极选择特征。
DOI：
10.1038/ejhg.2016.181
复制
发表时间：
2017-04-01
影响因子：
5.2
通讯作者：
Teo, Yik-Ying
中科院分区：
文献类型：
--
作者：
Liu, Xuanyao;Lu, Dongsheng;Teo, Yik-Ying
亚洲多样性项目（Asian Diversity Project， ADP）收集了37个亚洲大都市和少数民族人口，通过50多万个标记进行了密集的基因分型，以研究遗传多样性和积极自然选择的模式。对ADP种群进行了种群结构分析，并根据种群的地理信息将ADP种群划分为4个主要类群。通过应用高度敏感的算法haploPS来定位正选择的基因组特征，在至少一个种群中确定了140个不同的基因组区域，显示出正选择的证据。我们检查了在多个种群中选择的区域的信号共享程度，并观察到种群以类似于祖先进化枝的系统发育定义的方式聚集。特别是，与来自其他地理区域的人口相比，主要位于南亚的人口经历了相当不同的适应。在多个地理区域中存在的积极选择的签名被预测为更老，并且在不同区域的人口分离之前出现。相反，在单一种群中出现的选择信号往往频率较低，因此可以归因于最近的进化事件。
The Asian Diversity Project (ADP) assembled 37 cosmopolitan and ethnic minority populations in Asia that have been densely genotyped across over half a million markers to study patterns of genetic diversity and positive natural selection. We performed population structure analyses of the ADP populations and divided these populations into four major groups based on their genographic information. By applying a highly sensitive algorithm haploPS to locate genomic signatures of positive selection, 140 distinct genomic regions exhibiting evidence of positive selection in at least one population were identified. We examined the extent of signal sharing for regions that were selected in multiple populations and observed that populations clustered in a similar fashion to that of how the ancestry clades were phylogenetically defined. In particular, populations predominantly located in South Asia underwent considerably different adaptation as compared with populations from the other geographical regions. Signatures of positive selection present in multiple geographical regions were predicted to be older and have emerged prior to the separation of the populations in the different regions. In contrast, selection signals present in a single population group tended to be of lower frequencies and thus can be attributed to recent evolutionary events.