Relaxin/RXFP1 signaling in prostate cancer progression.
Relaxin/RXFP1 signaling in prostate cancer progression.
复制标题
DOI：
10.1111/j.1749-6632.2008.03793.x
复制
发表时间：
2009-04
影响因子：
5.2
通讯作者：
Agoulnik AI
中科院分区：
文献类型：
--
作者：
Feng S;Agoulnik IU;Li Z;Han HD;Lopez-Berestein G;Sood A;Ittmann MM;Agoulnik AI
我们已经证明松弛素肽的表达在复发的人前列腺癌中显著升高。松弛素刺激增加迁移，侵袭力，增殖和粘附的LNCaP和PC 3细胞在体外。在内源性松弛素/RXFP 1表达或信号传导抑制后，观察到对细胞表型的相反影响。我们发现，在TRAMP男性中，松弛素过表达转基因的前列腺癌进展加快，TRAMP、RXFP 1缺陷的男性存活时间更长。使用siRNA瘤内注射抑制裸鼠中PC 3异种移植物中RXFP 1表达导致肿瘤大小、细胞增殖和转移率降低。
We have shown that relaxin peptide expression was significantly elevated in recurrent human prostate cancer. Stimulation with relaxin increased migration, invasiveness, proliferation, and adhesion of LNCaP and PC3 cells in vitro. Opposite effects on cellular phenotype were observed after suppression of endogenous relaxin/RXFP1 expression or signaling. We showed an accelerated progression of prostate cancer in TRAMP males with transgenic relaxin overexpression and a longer survival of TRAMP, RXFP1-deficient males. Suppression of RXFP1 expression in PC3 xenografts in nude mice using siRNA intratumoral injections resulted in decrease of tumor size, cell proliferation, and metastasis rate.
影响因子：
56.9
作者：
Hsu, SY;Nakabayashi, K;Hsueh, AJW
通讯作者：
Hsueh, AJW
影响因子：
4.8
作者：
Scott, Daniel J.;Layfield, Sharon;Bathgate, Ross A. D.
通讯作者：
Bathgate, Ross A. D.
影响因子：
11.5
作者：
Feng, Shu;Agoulnik, Irina U.;Agoulnik, Alexander I.
通讯作者：
Agoulnik, Alexander I.