Ebola virus disease, stigmatization, peritraumatic distress, and posttraumatic stress disorder in the Democratic Republic of the Congo: A moderated mediation model
Ebola virus disease, stigmatization, peritraumatic distress, and posttraumatic stress disorder in the Democratic Republic of the Congo: A moderated mediation model
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DOI：
10.1016/j.jad.2021.06.047
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发表时间：
2021-07-01
影响因子：
6.6
通讯作者：
Guerrier, Mireille
中科院分区：
文献类型：
--
作者：
Cenat, Jude Mary;Kokou-Kpolou, Cyrille Kossigan;Guerrier, Mireille
背景：在受高死亡率流行病影响的个体中，加重创伤后应激障碍(PTSD)症状发展的机制尚不清楚。本研究调查了受埃博拉病毒病(EVD)疫情影响的人群中创伤后应激障碍(PTSD)的患病率和相关危险因素，并调查了肿瘤周围痛苦是否在暴露于EVD的水平对PTSD症状的影响中起到中介作用，以及污名化的调节作用。方法：样本包括1614名刚果民主共和国(DRC)埃博拉患者(50%为女性)。参与者完成了DSM-5的创伤后应激障碍检查表、肿瘤周围痛苦问卷，以及评估与EVD相关的暴露和污名程度的措施。描述性分析和缓和的调解模型被计算出来。结果：共有58.81%的参与者(95%可信区间：56.41%；61.21%)符合创伤后应激障碍的诊断标准。生活在农村地区的参与者表现出更大的风险，而男性和女性之间没有显著差异。在暴露于EVD和创伤后应激障碍症状之间的联系中，肿瘤周围的痛苦起了部分中介作用。此外，这种关系因与埃博拉病毒病有关的污名化而受到缓和。局限性：由于设计是横断面的，这项研究无法检验受EVD影响的社区中创伤后应激障碍症状的因果关系。结论：这项研究表明，在受EVD影响的人群中，创伤后应激障碍的患病率很高，并有重要的危险因素。它指出了有助于在受影响社区制定和实施预防和干预计划的要素。
Background: Mechanisms worsening the development of Posttraumatic stress disorder (PTSD) symptoms among individuals affected by high-mortality epidemics are unclear. This study examined the prevalence of PTSD and related risk factors among populations affected by the Ebola virus disease (EVD) outbreak, and investigated whether peritraumatic distress mediates the impact of exposure level to EVD on PTSD symptoms, and the moderation role of stigmatization. Methods: The sample included 1614 participants (50% women) affected by EVD in Democratic Republic of the Congo (DRC). Participants completed the PTSD Check-List for DSM-5, Peritraumatic Distress Inventory, and measures evaluating levels of exposure and stigmatization related to EVD. Descriptive analyses and a moderated mediation model were computed. Results: A total of 58.81% participants (95% CI: 56.41%; 61.21%) met PTSD diagnostic criteria. Participants living in rural areas presented greater risk, while there is no significant difference between men and women. Peritraumatic distress mediated partially the association between exposure to EVD and PTSD symptoms. Moreover, this relationship was moderated by stigmatization related to EVD. Limitations: As the design was cross-sectional, this study could not examine the causality of PTSD symptoms among communities affected by EVD. Conclusions: This study shows high prevalence rates and important risk factors associated with PTSD in populations affected by EVD. It indicates elements that could help to develop and implement prevention and intervention programs in affected communities.